Designing cell function: assembly of synthetic gene circuits for cell biology applications
M Xie, M Fussenegger - Nature Reviews Molecular Cell Biology, 2018 - nature.com
Synthetic biology is the discipline of engineering application-driven biological functionalities
that were not evolved by nature. Early breakthroughs of cell engineering, which were based …
that were not evolved by nature. Early breakthroughs of cell engineering, which were based …
Synthetic biology: applications come of age
AS Khalil, JJ Collins - Nature Reviews Genetics, 2010 - nature.com
Synthetic biology is bringing together engineers and biologists to design and build novel
biomolecular components, networks and pathways, and to use these constructs to rewire …
biomolecular components, networks and pathways, and to use these constructs to rewire …
An electrogenetic interface to program mammalian gene expression by direct current
J Huang, S Xue, P Buchmann, AP Teixeira… - Nature …, 2023 - nature.com
Wearable electronic devices are playing a rapidly expanding role in the acquisition of
individuals' health data for personalized medical interventions; however, wearables cannot …
individuals' health data for personalized medical interventions; however, wearables cannot …
Genomic mining of prokaryotic repressors for orthogonal logic gates
BC Stanton, AAK Nielsen, A Tamsir, K Clancy… - Nature chemical …, 2014 - nature.com
Genetic circuits perform computational operations based on interactions between freely
diffusing molecules within a cell. When transcription factors are combined to build a circuit …
diffusing molecules within a cell. When transcription factors are combined to build a circuit …
Large-scale design of robust genetic circuits with multiple inputs and outputs for mammalian cells
BH Weinberg, NTH Pham, LD Caraballo… - Nature …, 2017 - nature.com
Engineered genetic circuits for mammalian cells often require extensive fine-tuning to
perform as intended. We present a robust, general, scalable system, called'Boolean logic …
perform as intended. We present a robust, general, scalable system, called'Boolean logic …
The second wave of synthetic biology: from modules to systems
PEM Purnick, R Weiss - Nature reviews Molecular cell biology, 2009 - nature.com
Synthetic biology is a research field that combines the investigative nature of biology with
the constructive nature of engineering. Efforts in synthetic biology have largely focused on …
the constructive nature of engineering. Efforts in synthetic biology have largely focused on …
Synthetic biology in mammalian cells: next generation research tools and therapeutics
F Lienert, JJ Lohmueller, A Garg… - Nature reviews Molecular …, 2014 - nature.com
Recent progress in DNA manipulation and gene circuit engineering has greatly improved
our ability to programme and probe mammalian cell behaviour. These advances have led to …
our ability to programme and probe mammalian cell behaviour. These advances have led to …
Programmable single-cell mammalian biocomputers
S Ausländer, D Ausländer, M Müller, M Wieland… - Nature, 2012 - nature.com
Synthetic biology has advanced the design of standardized control devices that program
cellular functions and metabolic activities in living organisms. Rational interconnection of …
cellular functions and metabolic activities in living organisms. Rational interconnection of …
Emerging biomedical applications of synthetic biology
W Weber, M Fussenegger - Nature Reviews Genetics, 2012 - nature.com
Synthetic biology aims to create functional devices, systems and organisms with novel and
useful functions on the basis of catalogued and standardized biological building blocks …
useful functions on the basis of catalogued and standardized biological building blocks …
Diversity-based, model-guided construction of synthetic gene networks with predicted functions
Engineering artificial gene networks from modular components is a major goal of synthetic
biology. However, the construction of gene networks with predictable functions remains …
biology. However, the construction of gene networks with predictable functions remains …