Background Beta-lactam antibiotics (βLA) are the most commonly used antibiotics in the
intensive care unit (ICU). ICU patients present many pathophysiological features that cause …

Antimicrobials are among the most important and commonly prescribed drugs in the
management of critically ill patients and beta-lactams are the most common antibiotic class …

The alarming increase of resistance against multiple currently available antibiotics is leading
to a rapid lose of treatment options against infectious diseases. Since the antibiotic …

Initial adequate anti-infective therapy is associated with significantly improved clinical
outcomes for patients with severe infections. However, in critically ill patients, several …

The discovery of antibiotic drugs is considered one of the previous century's most important
medical discoveries (Medicine's 10 greatest discoveries. New Haven, CT: Yale University …

Optimization of antimicrobial dosing in accordance with pharmacokinetics/
pharmacodynamics targets can improve survival and clinical cure. Dosing regimens for …

Objectives: Augmented renal clearance (ARC) is a state of enhanced renal function
commonly observed in 30%–65% of critically ill patients despite normal serum creatinine …

Purpose Augmented renal clearance (ARC) is common in critically ill patients and may lead
to subtherapeutic levels of antibiotics, thus influencing clinical outcomes and emergence of …

Background: The pharmacokinetics, especially the volume of distribution (Vd), of ß-lactam
antibiotics can be altered in critically ill patients. This can lead to decreased serum …

The scope of TDM is broadening from the traditional focus on prevention of toxicity, to
include optimization of antibiotic exposure thereby improving patient outcomes. However …