Optimization of the treatment with beta-lactam antibiotics in critically ill patients—guidelines from the French Society of Pharmacology and Therapeutics (Société …
R Guilhaumou, S Benaboud, Y Bennis… - Critical Care, 2019 - Springer
Background Beta-lactam antibiotics (βLA) are the most commonly used antibiotics in the
intensive care unit (ICU). ICU patients present many pathophysiological features that cause …
intensive care unit (ICU). ICU patients present many pathophysiological features that cause …
Pharmacokinetics–pharmacodynamics issues relevant for the clinical use of beta-lactam antibiotics in critically ill patients
RP Veiga, JA Paiva - Critical Care, 2018 - Springer
Antimicrobials are among the most important and commonly prescribed drugs in the
management of critically ill patients and beta-lactams are the most common antibiotic class …
management of critically ill patients and beta-lactams are the most common antibiotic class …
Applications of the pharmacokinetic/pharmacodynamic (PK/PD) analysis of antimicrobial agents
E Asín-Prieto, A Rodríguez-Gascón, A Isla - Journal of Infection and …, 2015 - Elsevier
The alarming increase of resistance against multiple currently available antibiotics is leading
to a rapid lose of treatment options against infectious diseases. Since the antibiotic …
to a rapid lose of treatment options against infectious diseases. Since the antibiotic …
Therapeutic drug monitoring of anti-infective agents in critically ill patients
NGL Jager, RM van Hest, J Lipman… - Expert review of …, 2016 - Taylor & Francis
Initial adequate anti-infective therapy is associated with significantly improved clinical
outcomes for patients with severe infections. However, in critically ill patients, several …
outcomes for patients with severe infections. However, in critically ill patients, several …
Antibiotic therapy as personalized medicine–general considerations and complicating factors
The discovery of antibiotic drugs is considered one of the previous century's most important
medical discoveries (Medicine's 10 greatest discoveries. New Haven, CT: Yale University …
medical discoveries (Medicine's 10 greatest discoveries. New Haven, CT: Yale University …
Pharmacokinetic/pharmacodynamic considerations for the optimization of antimicrobial delivery in the critically ill
D Tsai, J Lipman, JA Roberts - Current opinion in critical care, 2015 - journals.lww.com
Optimization of antimicrobial dosing in accordance with pharmacokinetics/
pharmacodynamics targets can improve survival and clinical cure. Dosing regimens for …
pharmacodynamics targets can improve survival and clinical cure. Dosing regimens for …
Individualized antibiotic dosage regimens for patients with augmented renal clearance
AX Shi, Q Qu, HH Zhuang, XQ Teng, WX Xu… - Frontiers in …, 2023 - frontiersin.org
Objectives: Augmented renal clearance (ARC) is a state of enhanced renal function
commonly observed in 30%–65% of critically ill patients despite normal serum creatinine …
commonly observed in 30%–65% of critically ill patients despite normal serum creatinine …
Recommended antibiotic dosage regimens in critically ill patients with augmented renal clearance: a systematic review
CM Silva, JP Baptista, I Santos, P Martins - International Journal of …, 2022 - Elsevier
Purpose Augmented renal clearance (ARC) is common in critically ill patients and may lead
to subtherapeutic levels of antibiotics, thus influencing clinical outcomes and emergence of …
to subtherapeutic levels of antibiotics, thus influencing clinical outcomes and emergence of …
Pharmacokinetic and pharmacodynamic analysis of ceftazidime/avibactam in critically ill patients
GE Stein, CL Smith, A Scharmen, JM Kidd… - Surgical …, 2019 - liebertpub.com
Background: The pharmacokinetics, especially the volume of distribution (Vd), of ß-lactam
antibiotics can be altered in critically ill patients. This can lead to decreased serum …
antibiotics can be altered in critically ill patients. This can lead to decreased serum …
Optimizing dosing of antibiotics in critically ill patients
The scope of TDM is broadening from the traditional focus on prevention of toxicity, to
include optimization of antibiotic exposure thereby improving patient outcomes. However …
include optimization of antibiotic exposure thereby improving patient outcomes. However …