Antibiotic resistance is a global health emergency, with resistance detected to all antibiotics
currently in clinical use and only a few novel drugs in the pipeline. Understanding the …

Plasmids shape microbial communities' diversity, structure, and function. Nevertheless, we
lack a mechanistic understanding of how community structure and dynamics emerge from …

As mobile genetic elements, plasmids are central for our understanding of antimicrobial
resistance spread in microbial communities. Plasmids can have varying fitness effects on …

Natural transformation is a process where bacteria actively take up DNA from the
environment and recombine it into their genome or reconvert it into extra-chromosomal …

When antimicrobial resistant bacteria (ARB) and genes (ARGs) reach novel habitats, they
can become part of the habitat's microbiome in the long term if they are able to overcome the …

ABSTRACT Bacteriophages (“phages”) are hypothesized to be key drivers of bacterial
population dynamics, driving microbial community composition, but empirical support for this …

Human microbiome engineering is increasingly proposed as a way to modulate health
outcomes. However, one of the current limitations to engineering microbial communities in …

Antibiotic resistance represents one of the greatest threats to global health. The spread of
antibiotic resistance genes among bacteria occurs mostly through horizontal gene transfer …

It has been shown that an evolutionary tradeoff between vertical (host growth rate) and
horizontal (plasmid conjugation) transmissions contributes to global plasmid fitness. As …

In this work, we propose a multidimensional continuum model for plasmid dissemination in
biofilms via horizontal gene transfer. The model is formulated as a system of nonlocal partial …