Amino acid homeostasis and signalling in mammalian cells and organisms
S Bröer, A Bröer - Biochemical Journal, 2017 - portlandpress.com
Cells have a constant turnover of proteins that recycle most amino acids over time. Net loss
is mainly due to amino acid oxidation. Homeostasis is achieved through exchange of …
is mainly due to amino acid oxidation. Homeostasis is achieved through exchange of …
[HTML][HTML] Arginine metabolism revisited
SM Morris Jr - The Journal of nutrition, 2016 - Elsevier
Mammalian arginine metabolism is complex due to the expression of multiple enzymes that
utilize arginine as substrate and to interactions or competition between specific enzymes …
utilize arginine as substrate and to interactions or competition between specific enzymes …
Sestrin2 is a leucine sensor for the mTORC1 pathway
Leucine is a proteogenic amino acid that also regulates many aspects of mammalian
physiology, in large part by activating the mTOR complex 1 (mTORC1) protein kinase, a …
physiology, in large part by activating the mTOR complex 1 (mTORC1) protein kinase, a …
[HTML][HTML] Low protein intake is associated with a major reduction in IGF-1, cancer, and overall mortality in the 65 and younger but not older population
Mice and humans with growth hormone receptor/IGF-1 deficiencies display major reductions
in age-related diseases. Because protein restriction reduces GHR-IGF-1 activity, we …
in age-related diseases. Because protein restriction reduces GHR-IGF-1 activity, we …
Functional amino acids in nutrition and health
G Wu - Amino acids, 2013 - Springer
The recent years have witnessed growing interest in biochemistry, physiology and nutrition
of amino acids (AA) in growth, health and disease of humans and other animals. This results …
of amino acids (AA) in growth, health and disease of humans and other animals. This results …
The human SLC7A5 (LAT1): the intriguing histidine/large neutral amino acid transporter and its relevance to human health
SLC7A5, known as LAT1, belongs to the APC superfamily and forms a heterodimeric amino
acid transporter interacting with the glycoprotein CD98 (SLC3A2) through a conserved …
acid transporter interacting with the glycoprotein CD98 (SLC3A2) through a conserved …
Signal integration by mTORC1 coordinates nutrient input with biosynthetic output
CC Dibble, BD Manning - Nature cell biology, 2013 - nature.com
Flux through metabolic pathways is inherently sensitive to the levels of specific substrates
and products, but cellular metabolism is also managed by integrated control mechanisms …
and products, but cellular metabolism is also managed by integrated control mechanisms …
Isocaloric diets high in animal or plant protein reduce liver fat and inflammation in individuals with type 2 diabetes
M Markova, O Pivovarova, S Hornemann, S Sucher… - Gastroenterology, 2017 - Elsevier
Background & Aims Nonalcoholic fatty liver disease (NAFLD) is associated with increased
risk of hepatic, cardiovascular, and metabolic diseases. High-protein diets, rich in …
risk of hepatic, cardiovascular, and metabolic diseases. High-protein diets, rich in …
[HTML][HTML] Keeping the eIF2 alpha kinase Gcn2 in check
BA Castilho, R Shanmugam, RC Silva… - … et Biophysica Acta (BBA …, 2014 - Elsevier
The protein kinase Gcn2 is present in virtually all eukaryotes and is of increasing interest
due to its involvement in a large array of crucial biological processes. Some of these are …
due to its involvement in a large array of crucial biological processes. Some of these are …