Postsynaptic nAChRs in the peripheral nervous system are critical for neuromuscular and
autonomic neurotransmission. Pre-and peri-synaptic nAChRs in the brain modulate …

The α7 nicotinic acetylcholine receptor is a pentameric ligand-gated ion channel that plays
an important role in cholinergic signaling throughout the nervous system. Its unique …

We discuss models for the activation and desensitization of α7 nicotinic acetylcholine
receptors (nAChRs) and the effects of efficacious type II positive allosteric modulators …

Nicotinic acetylcholine receptors (nAChRs) are pentameric ligand-gated ion channels
involved in the modulation of essential brain functions such as memory, learning, and …

Considerable progress has been made in recent years towards the identification and
characterisation of novel subtype-selective modulators of nicotinic acetylcholine receptors …

Background The α7 nicotinic acetylcholine receptor (α7 nAChR) negatively regulates the
synthesis and release of pro-inflammatory cytokines by immune cells. Our previous studies …

It has been almost 20 years since the discovery and crystallization of a structural surrogate,
the Lymnaea stagnalis acetylcholine binding protein (Ls-AChBP), comprising the …

Current treatments against organophosphate poisoning (OPP) do not directly address
effects mediated by the overstimulation of nicotinic acetylcholine receptors (nAChR). Non …

Several antidepressants inhibit nicotinic acetylcholine receptors (nAChRs) in a non-
competitive and voltage-dependent fashion. Here, we asked whether antidepressants with a …