T cells are crucial for immune functions to maintain health and prevent disease. T cell
development occurs in a stepwise process in the thymus and mainly generates CD4+ and …

Several mechanisms and cell types are involved in the regulation of the immune response.
These include mostly regulatory T cells (Tregs), regulatory macrophages (Mregs), myeloid …

Immunosuppressive regulatory T cells (Tregs) provide a main mechanism of tumor immune
evasion. Targeting Tregs, especially in the tumor microenvironment (TME), continues to be …

Nanozyme-mediated tumor catalytic therapy has recently garnered attention as a means of
destroying tumor cells and eliciting anti-tumor immune responses. Herein, a copper-doped …

Human regulatory T cells (Tregs) are crucial regulators of tissue repair, autoimmune
diseases, and cancer. However, it is challenging to inhibit the suppressive function of Tregs …

Although targeting the tumor metabolism is performed in cooperation with immunotherapy in
the era of precision oncology, ignorance of immune cells' metabolism has resulted in …

Immunotherapy has made significant strides in cancer treatment, particularly through
immune checkpoint blockade (ICB), which has shown notable clinical benefits across …

The immune system plays critical roles in both autoimmunity and cancer, diseases at
opposite ends of the immune spectrum. Autoimmunity arises from loss of T cell tolerance …

Regulatory T cells (Tregs) are among the most abundant suppressive cells, which infiltrate
and accumulate in the tumor microenvironment, leading to tumor escape by inducing anergy …

Hepatocellular carcinoma (HCC) is one of the most lethal and prevalent human
malignancies, leading to poor prognosis due to its high recurrence and metastasis rates. In …