Although osteoarthritis (OA) was historically referred to as the non-inflammatory arthritis, it is
now considered a condition involving persistent low-grade inflammation and activation of …

Chronic pain is a substantial personal and societal burden worldwide. Osteoarthritis (OA) is
one of the leading causes of chronic pain and is increasing in prevalence in accordance …

Osteoarthritis (OA) and posttraumatic OA (PTOA) are caused by an imbalance in catabolic
and anabolic processes in articular cartilage and proinflammatory changes throughout the …

There is a well-established historical observation that structural joint damage by plain X-ray
correlates poorly with symptomatic disease in osteoarthritis (OA). This is often attributed to …

Background To identify a synovial fluid (SF) biomarker profile characteristic of individuals
with an inflammatory osteoarthritis (OA) endotype. Methods A total of 48 knees (of 25 …

The aim of this study was to identify inflammatory mediators of potential clinical relevance in
synovial fluid (SF) samples of patients with knee osteoarthritis (OA). Therefore, radiographic …

Monocyte chemoattractant protein‐1, also called chemokine (C‐C motif) ligand 2 (CCL2) or
small inducible cytokine A2, is an inflammatory mediator capable of recruiting monocytes …

Joint distraction, the prolonged mechanical separation of the bones at a joint, has emerged
as a joint-preserving treatment for end-stage osteoarthritis, with the gradually growing …

Osteoarthritis (OA) is a prevalent degenerative disease accompanied by the activation of
innate and adaptive immune systems-associated inflammatory responses. Due to the local …

Background Trauma-or osteoarthritis-related cartilage damage resulted in functional decline
of joints and heavy burden of public health. Recently, the reparative role of mesenchymal …