Bioorthogonal reactions that proceed readily under physiological conditions without
interference from biomolecules have found widespread application in the life sciences …

Although proteolysis targeting chimeras (PROTACs) have become promising therapeutic
modalities, important concerns exist about the potential toxicity of the approach owing to …

Biomaterials play a critical role in technologies intended to deliver therapeutic agents in
clinical settings. Recent explosion of our understanding of how cells utilize nucleic acids has …

Current antibody-drug conjugates (ADCs) target internalising receptors on cancer cells
leading to intracellular drug release. Typically, only a subset of patients with solid tumours …

A desired goal of targeted cancer treatments is to achieve high tumor specificity with minimal
side effects. Despite recent advances, this remains difficult to achieve in practice as most …

Dissociative bioorthogonal reactions allow for chemically controlling the release of bioactive
agents and reporter probes. Here we describe 3-isocyanopropyl substituents as masking …

The high rate of the 'click-to-release'reaction between an allylic substituted trans-
cyclooctene linker and a tetrazine activator has enabled exceptional control over chemical …

Although the clearance of senescent cells has been proven to slow down the aging process
and promote anti‐cancer chemotherapy, the development of senolytics remains challenging …

The inverse‐electron‐demand Diels–Alder/pyridazine elimination tandem reaction, in which
the allylic substituent on trans‐cyclooctene is eliminated following reaction with tetrazines, is …

The development of abiotic chemical reactions that can be performed in an organelle-
specific manner can provide new opportunities in drug delivery and cell and chemical …