Copper trafficking system in cells: insights into coordination chemistry and toxicity
J Han - Dalton Transactions, 2023 - pubs.rsc.org
Transition metal ions, such as copper, are indispensable components in the biological
system. Copper ions which primarily exist in two major oxidation states Cu (I) and Cu (II) play …
system. Copper ions which primarily exist in two major oxidation states Cu (I) and Cu (II) play …
Characterization of Uranyl (UO22+) Ion Binding to Amyloid Beta (Aβ) Peptides: Effects on Aβ Structure and Aggregation
E Berntsson, F Vosough, A Noormägi… - ACS Chemical …, 2023 - ACS Publications
Uranium (U) is naturally present in ambient air, water, and soil, and depleted uranium (DU)
is released into the environment via industrial and military activities. While the radiological …
is released into the environment via industrial and military activities. While the radiological …
New mescaline-related N-acylhydrazone and its unsubstituted benzoyl derivative: Promising metallophores for copper-associated deleterious effects relief in …
A Carvalho, BM Barbosa, JS Flores… - Journal of Inorganic …, 2023 - Elsevier
Alzheimer's disease (AD) is related to the presence of extracellular aggregated amyloid-β
peptide (Aβ), which binds copper (II) with high affinity in its N-terminal region. In this sense …
peptide (Aβ), which binds copper (II) with high affinity in its N-terminal region. In this sense …
[HTML][HTML] Computational assessment of the impact of Cu(II) and Al(III) on β-amyloid42 fibrils: Binding sites, structural stability, and possible physiological implications
One of Alzheimer's disease major hallmarks is the aggregation of β-amyloid peptide, a
process in which metal ions play an important role. In the present work, an integrative …
process in which metal ions play an important role. In the present work, an integrative …
Cu (II) Specifically Disassembles Insulin Amyloid Nanostructures via Direct Interaction with Cross-β Fibrils
In this work, we demonstrate direct evidence of the antiamyloid potential of Cu (II) ions
against amyloid formation of insulin. The Cu (II) ions were found to efficiently disassemble …
against amyloid formation of insulin. The Cu (II) ions were found to efficiently disassemble …
Interplay between Copper, Phosphatidylserine, and α-Synuclein Suggests a Link between Copper Homeostasis and Synaptic Vesicle Cycling
X Teng, E Stefaniak, KR Willison… - ACS Chemical …, 2024 - ACS Publications
Copper homeostasis is critical to the functioning of the brain, and its breakdown is linked
with many brain diseases. Copper is also known to interact with the negatively charged lipid …
with many brain diseases. Copper is also known to interact with the negatively charged lipid …
Glycyl-l-histidyl-l-lysine prevents copper- and zinc-induced protein aggregation and central nervous system cell death in vitro
JH Min, H Sarlus, RA Harris - Metallomics, 2024 - academic.oup.com
Common features of neurodegenerative diseases are oxidative and inflammatory
imbalances as well as the misfolding of proteins. An excess of free metal ions can be …
imbalances as well as the misfolding of proteins. An excess of free metal ions can be …
APP‐C31: An Intracellular Promoter of Both Metal‐Free and Metal‐Bound Amyloid‐β40 Aggregation and Toxicity in Alzheimer's Disease
Intracellular C‐terminal cleavage of the amyloid precursor protein (APP) is elevated in the
brains of Alzheimer's disease (AD) patients and produces a peptide labeled APP‐C31 that is …
brains of Alzheimer's disease (AD) patients and produces a peptide labeled APP‐C31 that is …
Probing the structure of toxic amyloid-β oligomers with electron spin resonance and molecular modeling
Structural models of the toxic species involved in the development of Alzheimer's disease
are of utmost importance to understand the molecular mechanism and to describe early …
are of utmost importance to understand the molecular mechanism and to describe early …
Redox behaviour of Cu-Aβ (4-16) complexes related to Alzheimer's Disease
The development of Alzheimer's Disease (AD) has been linked to abnormal quantities of β-
amyloid peptides in the brain. The majority of studies have focussed on Aβ (1-40/42) …
amyloid peptides in the brain. The majority of studies have focussed on Aβ (1-40/42) …