Methionine aminopeptidases: Potential therapeutic target for microsporidia and other microbes

BC Das, P Chokkalingam, MA Shareef… - Journal of Eukaryotic …, 2024 - Wiley Online Library
Methionine aminopeptidases (MetAPs) have emerged as a target for medicinal chemists in
the quest for novel therapeutic agents for treating cancer, obesity, and other disorders …

Novel Antibacterial Targets in Protein Biogenesis Pathways

US Potteth, T Upadhyay, S Saini, I Saraogi - Chembiochem, 2022 - Wiley Online Library
Antibiotic resistance has emerged as a global threat due to the ability of bacteria to quickly
evolve in response to the selection pressure induced by anti‐infective drugs. Thus, there is …

In silico study of novel marine alkaloid jolynamine and other marine compounds via molecular docking, MM-GBSA binding energy prediction, ADMET evaluation, and …

S Gul, AM Khan, ST Ali, S Rizwan - Natural Product Research, 2024 - Taylor & Francis
In this research article bacterial (Escherichia coli and Pseudomonas aeruginosa) and fungal
(Aspergillus niger and Candida albicans) enzymes are used for molecular docking of novel …

Synthesis and Antibacterial Evaluation of 3,4‐Dihydro‐1H‐benzo[b]azepine‐2,5‐dione Derivatives

R Akunuri, M Vadakattu, G Kaul, A Akhir… - …, 2022 - Wiley Online Library
Fused‐azepinones are interesting heterocyclic scaffolds present in various natural products
and synthetic derivatives with potent kinase inhibition, anti‐cancer, anti‐inflammatory, anti …

In Silico Design and in Vitro Assessment of Bicyclic Trifluoromethylated Pyrroles as New Antibacterial and Antifungal Agents

D Hodyna, A Klipkov, M Kachaeva… - Chemistry & …, 2024 - Wiley Online Library
QSAR studies on the number of compounds tested as S. aureus inhibitors were performed
using an interactive Online Chemical Database and Modeling Environment (OCHEM) web …

The identification of inhibitory compounds of Rickettsia prowazekii methionine aminopeptidase for antibacterial applications

TR Helgren, ES Seven, C Chen, TE Edwards… - Bioorganic & medicinal …, 2018 - Elsevier
Methionine aminopeptidase (MetAP) is a dinuclear metalloprotease responsible for the
cleavage of methionine initiator residues from nascent proteins. MetAP activity is necessary …

Methionine aminopeptidases

T Heinrich, FT Zenke, J Bomke, J Gunera, A Wegener… - Metalloenzymes, 2024 - Elsevier
Methionine aminopeptidases (MetAPs) have been investigated for decades, and
pharmacological inhibition of MetAPs has been pursued to treat diseases such as viral …

Synthesis, development and biological evaluation of new antimicrobial compounds

VSK Pallabothula - 2024 - dspace.cuni.cz
This doctoral dissertation is a collection of published works with commentary along with
various contributions throughout the doctoral study program. In our research work, we …

[PDF][PDF] Molecular Docking Studies of Novel Furan-azetidinone Hybrids as Potential Inhibitors of Escherichia coli

J Jays, S Mohan, J Saravanan - Indian J. Pharm. Educ. Res., 2019 - ijper.org
Escherichia coli is the predominant gram negative bacteria responsible for a variety of
hospital-acquired infections and urinary tract infections. As the bacterial strains are rapidly …

Grundlegende Untersuchungen zur Entwicklung Bioorthogonaler Reaktionssysteme auf Basis von Olefinmetathesereaktionen

T Benkert - 2024 - search.proquest.com
Die vorliegende Arbeit untersuchte verschiedene Wege zur Herstellung einer BRS mit einer
RCM als abschließender, entscheidender Reaktion, basierend auf vielversprechenden …