[HTML][HTML] What Remains to Be Discovered in Schizophrenia Therapeutics: Contributions by Advancing the Molecular Mechanisms of Drugs for Psychosis and …
Schizophrenia is a frequently debilitating and complex mental disorder affecting
approximately 1% of the global population, characterized by symptoms such as …
approximately 1% of the global population, characterized by symptoms such as …
Cell type specification and diversity in subpallial organoids
Neural organoids have emerged as valuable tools for studying the developing brain,
sparking enthusiasm and driving their adoption in disease modeling, drug screening, and …
sparking enthusiasm and driving their adoption in disease modeling, drug screening, and …
Corticolimbic circuitry as a druggable target in schizophrenia spectrum disorders: a narrative review
Schizophrenia spectrum disorders (SSD) involve disturbances in the integration of
perception, emotion and cognition. The corticolimbic system is an interacting set of cortical …
perception, emotion and cognition. The corticolimbic system is an interacting set of cortical …
[HTML][HTML] Dysfunctional Parvalbumin Neurons in Schizophrenia and the Pathway to the Clinical Application of Kv3 Channel Modulators
M Yanagi, M Hashimoto - International Journal of Molecular Sciences, 2024 - mdpi.com
Based on the pathophysiological changes observed in schizophrenia, the gamma-
aminobutyric acid (GABA) hypothesis may facilitate the development of targeted treatments …
aminobutyric acid (GABA) hypothesis may facilitate the development of targeted treatments …
Glutamate-Mediated Excitotoxicity in the Pathogenesis and Treatment of Neurodevelopmental and Adult Mental Disorders
Glutamate is the main excitatory neurotransmitter in the brain wherein it controls cognitive
functional domains and mood. Indeed, brain areas involved in memory formation and …
functional domains and mood. Indeed, brain areas involved in memory formation and …
Diazepam modulates hippocampal CA1 functional connectivity in people at clinical high-risk for psychosis
Background: Preclinical evidence suggests that diazepam enhances hippocampal γ-
aminobutyric acid (GABA) signalling and normalises a psychosis-relevant cortico-limbic …
aminobutyric acid (GABA) signalling and normalises a psychosis-relevant cortico-limbic …
PV+ optogenetic stimulations at specific frequencies in specific brain regions can restore navigational flexibility in an acute MK801 mouse model of schizophrenia
Impairments of decision-making and behavioral flexibility in schizophrenia (SCZ) are
currently the most investigated features. One convincing hypothesis explaining this cognitive …
currently the most investigated features. One convincing hypothesis explaining this cognitive …
Nanoelectrochemical analysis of neurotransmitter release in cell models of Alzheimer's disease
A Pradhan - 2024 - gupea.ub.gu.se
Neurotransmitter release and binding to receptors are tightly regulated, and aberrant
changes can cause neuropsychiatric and neurodegenerative disorders. Alzheimer's disease …
changes can cause neuropsychiatric and neurodegenerative disorders. Alzheimer's disease …
[引用][C] An introduction to the special issue" Sam Enna legacy of Excellence"
J Piette, L LeCount - Biochemical pharmacology, 2024 - pubmed.ncbi.nlm.nih.gov