Klotho has been recognized as a gene involved in the aging process in mammals for over
30 years, where it regulates phosphate homeostasis and the activity of members of the …

Cardiovascular disease is the leading cause of death in patients with chronic kidney disease
(CKD). As CKD progresses, CKD-specific risk factors, such as disordered mineral …

Objectives: Vascular calcification is highly prevalent in patients with chronic kidney disease.
Increased plasma trimethylamine N-oxide (TMAO), a gut microbiota-dependent product …

Vascular calcification (VC) is highly prevalent in aging, diabetes mellitus, and chronic kidney
disease (CKD). VC is a strong predictor of cardiovascular morbidity and mortality in the CKD …

Irisin protects the cardiovascular system against vascular diseases. However, its role in
chronic kidney disease (CKD)-associated vascular calcification (VC) and the underlying …

Chronic kidney disease (CKD) is an inherently systemic disease that refers to a long-term
loss of kidney function. The progression of CKD has repercussions for other organs, leading …

The extracellular domain of transmembrane alpha-Klotho (αKlotho, hereinafter simply called
Klotho) is cleaved by secretases and released into the circulation as soluble Klotho. Soluble …

Cardiovascular disease is the leading cause of death worldwide. New therapeutic strategies
are aimed to modulate the athero-inflammatory process that partially orchestrates underlying …

Recent studies have revealed critical roles of transforming growth factor-β1 (TGF-β1) and
microRNA-132 (miR-132), a downstream mediator of TGF-β1, in the pathogenesis of cardiac …

Klotho is an anti-ageing protein that functions in many pathways that govern ageing, like
regulation of phosphate homeostasis, insulin signaling, and Wnt signaling. Klotho …