Abstract Receptor-interacting protein kinase-3 (RIPK3, or RIP3) is an essential protein in the
“programmed” and “regulated” cell death pathway called necroptosis. Necroptosis is …

The discovery that the tumour necrosis factor-related apoptosis-inducing ligand (TRAIL) can
induce apoptosis of cancer cells without causing toxicity in mice has led to the in-depth study …

Unleashing the immune system with immune checkpoint inhibitors (ICI) has significantly
improved overall survival for subsets of patients with stage III/IV cancer. However, many …

Oxidative stress caused by an imbalanced metabolism and an excess of reactive oxygen
species (ROS) lead to a range of health disorders in humans. Our endogenous antioxidant …

Necroptosis is a caspase-independent form of regulated cell death executed by the receptor-
interacting protein kinase 1 (RIP1), RIP3, and mixed lineage kinase domain-like protein …

The lab of Jürg Tschopp was the first to report on the crucial role of receptor-interacting
protein kinase 1 (RIPK1) in caspase-independent cell death. Because of this pioneer …

Although TRAIL (tumor necrosis factor (TNF)-related apoptosis inducing ligand) is a well-
known apoptosis inducer, we have previously demonstrated that acidic extracellular pH …

A role for cellular inhibitors of apoptosis (IAPs [cIAPs]) in preventing CD95 death has been
suspected but not previously explained mechanistically. In this study, we find that the loss of …

Programmed necrosis is important in many (patho) physiological settings. For specific
therapeutic intervention, however, a better knowledge is required whether necrosis occurs …

Cancer metastasis, the process of cancer cell migration from a primary to distal location,
typically leads to a poor patient prognosis. Hematogenous metastasis is initiated by …