As a non-canonical fibroblast growth factor, fibroblast growth factor 21 (FGF21) functions as
an endocrine hormone that signals to distinct targets throughout the body. Interest in …

Cardiovascular and metabolic disease (CVMD) is becoming increasingly prevalent in
developed and developing countries with high morbidity and mortality. In recent years …

Obesity increases the risk of mortality because of metabolic sequelae such as type 2
diabetes and cardiovascular disease. Thermogenesis by adipocytes can counteract obesity …

Adipose tissue can recruit catabolic adipocytes that utilize chemical energy to dissipate heat.
This process occurs either by uncoupled respiration through uncoupling protein 1 (UCP1) or …

The discovery of functional brown adipose tissue (BAT) in adult humans and the possibility
to recruit beige cells with high thermogenic potential within white adipose tissue (WAT) …

Brown and brite adipocytes contribute to energy expenditure through nonshivering
thermogenesis. Though these cell types are thought to arise primarily from the de novo …

Gut microbiota deficient mice demonstrate accelerated glucose clearance. However, which
tissues are responsible for the upregulated glucose uptake remains unresolved, with …

Intermittent fasting is a beneficial dietary treatment for obesity. But the response of each
distinct adipose depot is currently poorly defined. Here we explore the response of key …

Fibroblast growth factor 21 is an evolutionarily conserved factor that plays multiple important
roles in metabolic homeostasis. During the past two decades, extensive investigations have …

Thyroid hormone (T3) and its nuclear receptors (TR) are important regulators of energy
expenditure and adaptive thermogenesis, notably through their action in the brown adipose …