Heterochromatin plays a fundamental role in gene regulation, genome integrity, and
silencing of repetitive DNA elements. Histone modifications are essential for the …

Long noncoding RNA (lncRNA) is a pivotal factor regulating various aspects of genome
activity. Genome regulation via DNA methylation and post-translational histone …

Human cancer cell lines are an integral part of drug discovery practices. However, modeling
the complexity of cancer utilizing these cell lines on standard plastic substrata, does not …

The inheritance of parental histones across the replication fork is thought to mediate
epigenetic memory. Here, we reveal that fission yeast Mrc1 (CLASPIN in humans) binds H3 …

HP1 proteins are central to the assembly and spread of heterochromatin containing histone
H3K9 methylation. The chromodomain (CD) of HP1 proteins specifically recognizes the …

Heterochromatin assembly, involving histone H3 lysine-9 methylation (H3K9me), is
nucleated at specific genomic sites but can self-propagate across extended domains and …

Argonaute proteins play a major part in transcriptional gene silencing in many organisms,
but their role in the nucleus of somatic mammalian cells remains elusive. Here, we have …

Heterochromatin assembly requires methylation of histone H3 lysine 9 (H3K9me) and
serves as a paradigm for understanding the importance of histone modifications in …

Abstract ATR-X (alpha-thalassemia/mental retardation, X-linked) syndrome is a human
congenital disorder that causes severe intellectual disabilities. Mutations in the ATRX gene …

DNA methylation is an important epigenetic mark in many eukaryotic organisms. De novo
DNA methylation in plants can be achieved by the RNA-directed DNA methylation (RdDM) …