One of the challenges in cancer chemotherapy is the low target to non-target ratio of
therapeutic agents which incur severe adverse effect on the healthy tissues. In this regard …

Neurodegenerative diseases are a heterogeneous group of disorders that are incurable and
characterized by the progressive degeneration of the function and structure of the central …

Background For several decades, intermediate metabolism and signal transduction have
been considered two independent entities. On one side stood the catabolic and anabolic …

A decline in energy is common in aging, and the restoration of mitochondrial bioenergetics
may offer a common approach for the treatment of numerous age‐associated diseases …

The free radical theory of aging proposes that reactive oxygen species (ROS)-induced
accumulation of damage to cellular macromolecules is a primary driving force of aging and a …

Ischemia causes AKI as a result of ATP depletion, and rapid recovery of ATP on reperfusion
is important to minimize tissue damage. ATP recovery is often delayed, however, because …

Oxidative/nitrosative stress and neuroinflammation are critical pathological processes in
cerebral ischemia-reperfusion injury, and their intimate interactions mediate neuronal …

Mitochondrial function and specifically its implication in cellular redox/oxidative balance is
fundamental in controlling the life and death of cells, and has been implicated in a wide …

Mitochondrial dysfunction and oxidative damage represent important pathological
mechanisms of myocardial ischemia-reperfusion injury (MI/RI). Searching for potential …

Old age is a major risk factor for cardiovascular diseases. Several lines of evidence in
experimental animal models have indicated the central role of mitochondria both in lifespan …