A biomarker describes a measurable indicator of a patient's clinical condition that can be
measured accurately and reproducibly. Biomarkers offer utility for diagnosis, prognosis …

Acute lung injury (ALI) and acute respiratory distress syndrome (ARDS) are common acute
and severe cases of the respiratory system with complicated pathogenesis and high …

Sepsis represents a dysregulated host response to infection leading to organ dysfunction.
Here, the pathogen triggers an initial exaggerated inflammatory-immune response that …

Background & Aims Circular RNAs (circRNAs) are a class of endogenous noncoding RNAs
that form covalently closed circles. Although circRNAs influence many biological processes …

After spinal cord injury (SCI), patients face many physical and psychological issues
including intestinal dysfunction and comorbidities, strongly affecting quality of life. The gut …

Mitochondria release many damage-associated molecular patterns (DAMPs) when cells are
damaged or stressed, with mitochondrial DNA (mtDNA) being. MtDNA activates innate …

Abstract MicroRNA-155 (miR-155) is implicated in the pathological processes of sepsis.
However, the function and regulatory mechanism of miR-155 in sepsis-induced …

Emerging evidence shows that after injury or infection, the mesenteric lymph acts as a
conduit for gut-derived toxic factors to enter the blood circulation, causing systemic …

Pneumonia is an inflammatory condition of the lung parenchyma initiated by aspirated
microorganisms into the lower airways from proximal sites, including the oral and nasal …

The complex pathophysiology of sepsis makes it a syndrome with limited therapeutic options
and a high mortality rate. Gram-negative bacteria containing lipopolysaccharides (LPS) in …