The past few decades have witnessed widespread research to challenge carcinogenesis;
however, it remains one of the most important health concerns with the worst prognosis and …

Today, pharmacognosy is considered a valuable science in the prevention and treatment of
diseases. Among herbals, Berberine is an isoquinoline alkaloid found in the Berberis …

Background Small extracellular vesicles (sEV) secreted by mesenchymal stem cells (MSC)
derived from human induced pluripotent stem cells (iPSC, iMSC-sEV) are considered to …

Abstract VEGFR2 (KDR/Flk1) signaling in endothelial cells (ECs) plays a central role in
angiogenesis. The P-type ATPase transporter ATP7A regulates copper homeostasis, and its …

Accumulated evidence indicates that autophagy is a response of cancer cells to various anti-
cancer therapies. Autophagy is designated as programmed cell death type II, and is …

Several functions of autophagy associated with proliferation, differentiation, and migration of
endothelial cells have been reported. Due to lack of models recapitulating angiogenic …

Immunotherapies, such as immune checkpoint inhibitors (ICIs) and chimeric antigen
receptor (CAR) T cells, have revolutionized the treatment of patients with advanced and …

Cancer is a serious disease with high mortality and morbidity worldwide. Natural products
have served as a major source for developing new anticancer drugs during recent decades …

Asparaginase is an important antileukemic agent extensively used worldwide but the
intrinsic glutaminase activity of this enzymatic drug is responsible for serious life threatening …

Abstract Cerebral Cavernous Malformation (CCM) is a vascular disease of proven genetic
origin, which may arise sporadically or is inherited as an autosomal dominant condition with …