Mammalian chromosomes form a hierarchical structure within the cell nucleus, from
chromatin loops, megabase (Mb)-sized topologically associating domains (TADs) to larger …

In eukaryotes, chromatin and DNA replication are intimately linked, whereby chromatin
impacts DNA replication control while genome duplication involves recovery of chromatin …

Faithful DNA replication is essential for genome integrity,,–. Under-replicated DNA leads to
defects in chromosome segregation, which are common during embryogenesis,,–. However …

The timing of DNA replication in mammals is crucial for minimizing errors and influenced by
genome usage and chromatin states. Replication timing in the newly formed mammalian …

Background The fatal diffuse midline gliomas (DMG) are characterized by an undruggable
H3K27M mutation in H3. 1 or H3. 3. K27M impairs normal development by stalling …

The totipotent one-cell embryo, or zygote, gives rise to all germ layers and extraembryonic
tissues that culminate in the development of a new organism. A zygote is produced at …

Mouse embryonic stem cells (mESCs) in the primed pluripotency state, which resembles the
post-implantation epiblast, can be de-differentiated in culture to a naive state that resembles …

Eukaryotic DNA replication is a tightly controlled process that occurs in two main steps, ie,
licensing and firing, which take place in the G1 and S phases of the cell cycle, respectively …

A largely stable genome is required for normal development, even as genetic change is an
integral aspect of reproduction, genetic adaptation and evolution. Recent studies highlight a …

Pronuclear transfer has been successfully used in human-assisted reproduction to suppress
the adverse effects of a defective oocyte cytoplasm or to bypass an idiopathic developmental …