It is well known that G1 to S phase transition is tightly regulated by the expression and
phosphorylation of a number of well‐characterized cyclins, cyclin‐dependent kinases and …

ABSTRACT p27Kip1 was first discovered as a key regulator of cell proliferation. The
canonical function of p27Kip1 is inhibition of cyclin-dependent kinase (CDK) activity. In …

The earliest step in creating the cerebral cortex is the specification of neuroepithelium to a
cortical fate. Using mouse genetic mosaics and timed inactivations, we demonstrated that …

The mechanisms responsible for the transcriptional silencing of pluripotency genes in
differentiated cells are poorly understood. We have observed that cells lacking the tumor …

Previously, we have shown that Wnt-5a strongly regulates dopaminergic neuron
differentiation by inducing phosphorylation of Dishevelled (Dvl). Here, we identify additional …

Wnts are a family of secreted proteins that regulate multiple steps of neural development
and stem cell differentiation. Two of them, Wnt1 and Wnt5a, activate distinct branches of Wnt …

Centrioles function as core components of centrosomes and as basal bodies for the
formation of cilia and flagella. Thus, effective control of centriole numbers is essential for …

Dishevelled-3 (Dvl3), a key component of the Wnt signaling pathways, acts downstream of
Frizzled (Fzd) receptors and gets heavily phosphorylated in response to pathway activation …

Embryonic stem cells (ESCs) represent not only a promising source of cells for cell
replacement therapy, but also a tool to study the molecular mechanisms underlying cellular …

Embryonic stem cells combine the features of robust proliferation with precise differentiation
capacity. p27 is a cell cycle inhibitor that is involved in the regulation of proliferation and …