The link between vascular dysfunction, bladder ischemia, and aging bladder dysfunction

KE Andersson, DB Boedtkjer… - Therapeutic advances in …, 2017 - journals.sagepub.com
The vascular supply to the human bladder is derived mainly from the superior and inferior
vesical arteries, the latter being directly connected to the internal iliac artery. Aging is …

Calcium signalling in pericytes

T Burdyga, L Borysova - Journal of vascular research, 2014 - karger.com
Recent advances in pericyte research have contributed to our understanding of the
physiology and pathophysiology of microvessels. The microvasculature consists of arteriolar …

Contractile elements and their sympathetic regulations in the pig urinary bladder: a species and regional comparative study

R Mitsui, K Lee, A Uchiyama, S Hayakawa… - Cell and tissue …, 2020 - Springer
Contractile behaviour of the urinary bladder and its sympathetic inhibition during storage
phases are not well understood. Here, we explore muscularis mucosae (MM) as a …

Role of capillary pericytes in the integration of spontaneous Ca2+ transients in the suburothelial microvasculature in situ of the mouse bladder

H Hashitani, R Mitsui… - The Journal of …, 2018 - Wiley Online Library
Key points In the bladder suburothelial microvasculature, pericytes in different microvascular
segments develop spontaneous Ca2+ transients with or without associated constrictions …

Mucosal signaling in the bladder

TC Chai, A Russo, S Yu, M Lu - Autonomic Neuroscience, 2016 - Elsevier
The bladder mucosa is comprised of the multilayered urothelium, lamina propria (LP),
microvasculature, and smooth muscle fibers (muscularis mucosae). The muscularis …

Role of PTHrP and sensory nerve peptides in regulating contractility of muscularis mucosae and detrusor smooth muscle in the guinea pig bladder

K Lee, R Mitsui, S Kajioka, S Naito… - The Journal of …, 2016 - auajournals.org
Purpose: We investigated the neurohumoral modulation of the contractility of bladder
muscularis mucosae (mucosa) compared with that of detrusor smooth muscle. Materials and …

Inhibition of vascular smooth muscle inward-rectifier K+ channels restores myogenic tone in mouse urinary bladder arterioles

NR Tykocki, AD Bonev, TA Longden… - American Journal …, 2017 - journals.physiology.org
Prolonged decreases in urinary bladder blood flow are linked to overactive and underactive
bladder pathologies. However, the mechanisms regulating bladder vascular reactivity are …

Role of pericytes in the initiation and propagation of spontaneous activity in the microvasculature

H Hashitani, R Mitsui - Smooth Muscle Spontaneous Activity: Physiological …, 2019 - Springer
The microvasculature is composed of arterioles, capillaries and venules. Spontaneous
arteriolar constrictions reduce effective vascular resistance to enhance tissue perfusion …

Synchrony of spontaneous Ca2+ activity in microvascular mural cells

R Mitsui, H Hashitani - Journal of Smooth Muscle Research, 2020 - jstage.jst.go.jp
Spontaneous rhythmic constrictions known as vasomotion are developed in several
microvascular beds in vivo. Vasomotion in arterioles is considered to facilitate blood flow …

Pacemaker role of pericytes in generating synchronized spontaneous Ca2+ transients in the myenteric microvasculature of the guinea-pig gastric antrum

H Hashitani, R Mitsui, S Masaki, DF Van Helden - Cell Calcium, 2015 - Elsevier
Abstract Properties of spontaneous Ca 2+ transients in the myenteric microvasculature of the
guinea-pig stomach were investigated. Specifically, we explored the spatio-temporal origin …