Cancer stem cells in hepatocellular carcinoma—from origin to clinical implications
Hepatocellular carcinoma (HCC) is an aggressive disease with a poor clinical outcome. The
cancer stem cell (CSC) model states that tumour growth is powered by a subset of tumour …
cancer stem cell (CSC) model states that tumour growth is powered by a subset of tumour …
[HTML][HTML] RNA methylation and cancer treatment
To this date, over 100 different types of RNA modification have been identified. Methylation
of different RNA species has emerged as a critical regulator of transcript expression. RNA …
of different RNA species has emerged as a critical regulator of transcript expression. RNA …
[HTML][HTML] Methyltransferase-like proteins in cancer biology and potential therapeutic targeting
YN Qi, Z Liu, LL Hong, P Li, ZQ Ling - Journal of Hematology & Oncology, 2023 - Springer
RNA modification has recently become a significant process of gene regulation, and the
methyltransferase-like (METTL) family of proteins plays a critical role in RNA modification …
methyltransferase-like (METTL) family of proteins plays a critical role in RNA modification …
[HTML][HTML] tRNA modification dynamics from individual organisms to metaepitranscriptomics of microbiomes
Summary tRNA is the most extensively modified RNA in cells. On average, a bacterial tRNA
contains 8 modifications per molecule and a eukaryotic tRNA contains 13 modifications per …
contains 8 modifications per molecule and a eukaryotic tRNA contains 13 modifications per …
RNA nucleotide methylation: 2021 update
Among RNA modifications, transfer of methylgroups from the typical cofactor S‐adenosyl‐l‐
methionine by methyltransferases (MTases) to RNA is by far the most common reaction …
methionine by methyltransferases (MTases) to RNA is by far the most common reaction …
[HTML][HTML] Balancing of mitochondrial translation through METTL8-mediated m3C modification of mitochondrial tRNAs
E Schöller, J Marks, V Marchand, A Bruckmann… - Molecular cell, 2021 - cell.com
Mitochondria contain a specific translation machinery for the synthesis of mitochondria-
encoded respiratory chain components. Mitochondrial tRNAs (mt-tRNAs) are also generated …
encoded respiratory chain components. Mitochondrial tRNAs (mt-tRNAs) are also generated …
Human transfer RNA modopathies: diseases caused by aberrations in transfer RNA modifications
T Chujo, K Tomizawa - The FEBS journal, 2021 - Wiley Online Library
tRNA molecules are post‐transcriptionally modified by tRNA modification enzymes.
Although composed of different chemistries, more than 40 types of human tRNA …
Although composed of different chemistries, more than 40 types of human tRNA …
[HTML][HTML] Epitranscriptomic regulation of cortical neurogenesis via Mettl8-dependent mitochondrial tRNA m3C modification
Increasing evidence implicates the critical roles of various epitranscriptomic RNA
modifications in different biological processes. Methyltransferase METTL8 installs 3 …
modifications in different biological processes. Methyltransferase METTL8 installs 3 …
[HTML][HTML] The RNA methyltransferase METTL8 installs m3C32 in mitochondrial tRNAsThr/Ser(UCN) to optimise tRNA structure and mitochondrial translation
N Kleiber, N Lemus-Diaz, C Stiller, M Heinrichs… - Nature …, 2022 - nature.com
Modified nucleotides in tRNAs are important determinants of folding, structure and function.
Here we identify METTL8 as a mitochondrial matrix protein and active RNA …
Here we identify METTL8 as a mitochondrial matrix protein and active RNA …
METTLing in stem cell and cancer biology
JG Tooley, JP Catlin, CES Tooley - Stem cell reviews and reports, 2023 - Springer
The methyltransferase-like (METTL) family is a diverse group of methyltransferases that can
methylate nucleotides, proteins, and small molecules. Despite this diverse array of …
methylate nucleotides, proteins, and small molecules. Despite this diverse array of …