TBX5 is a member of the T-box transcription factor family and is primarily known for its role in
cardiac and forelimb development. Human patients with dominant mutations in TBX5 are …

Atrial fibrillation (AF), the most common sustained cardiac arrhythmia encountered in clinical
practice, is associated with increased morbidity and mortality. Electrophysiologically, it is …

Tetralogy of Fallot (TOF) represents the most common form of cyanotic congenital heart
disease and accounts for significant morbidity and mortality in humans. Emerging evidence …

Abstract Background Holt-Oram syndrome (HOS) is an autosomal dominant disorder
characterised by upper limb anomalies and congenital heart defects. We present …

Holt-Oram syndrome (HOS) is an autosomal dominant condition characterised by the
association of congenital heart defect (CHD), with or without rhythm disturbances and radial …

Tetralogy of Fallot (TOF)(OMIM# 187500) is the most frequent conotruncal congenital heart
defect (CHD) with a range of intra‐and extracardiac phenotypes. TBX5 is a transcription …

The right ventricle has long been perceived as the “low pressure bystander” of the left
ventricle. Although the structure consists of, at first glance, the same cardiomyocytes as the …

This paper reviews the molecular basis of the clinical features of Holt–Oram syndrome
resulting from missense and extended protein mutations of the TBX5 gene as well as TBX5 …

Congenital heart disease (CHD) is the most common birth defect occurring in humans and
some transcriptional factors have been identified as causative. However, additional mutation …

TBX5 is a vital transcription factor involved in cardiac development in a dosage-dependent
manner. But little is known about the potential association of TBX5 3′ untranslated region …