Genome editing technologies operate by inducing site-specific DNA perturbations that are
resolved by cellular DNA repair pathways. Products of genome editors include DNA breaks …

TP53 is the most frequently mutated gene in human cancer. Functionally, p53 is activated by
a host of stress stimuli and, in turn, governs an exquisitely complex anti-proliferative …

Although p53 inactivation promotes genomic instability and presents a route to malignancy
for more than half of all human cancers,, the patterns through which heterogenous TP53 …

Genome editing has therapeutic potential for treating genetic diseases and cancer.
However, the currently most practicable approaches rely on the generation of DNA double …

Focal chromosomal amplification contributes to the initiation of cancer by mediating
overexpression of oncogenes,–, and to the development of cancer therapy resistance by …

Pan-cancer analyses that examine commonalities and differences among various cancer
types have emerged as a powerful way to obtain novel insights into cancer biology. Here we …

While mutations affecting protein-coding regions have been examined across many
cancers, structural variants at the genome-wide level are still poorly defined. Through …

Cancer is driven by genetic change, and the advent of massively parallel sequencing has
enabled systematic documentation of this variation at the whole-genome scale,–. Here we …

Current therapies for medulloblastoma, a highly malignant childhood brain tumour, impose
debilitating effects on the developing child, and highlight the need for molecularly targeted …

Chromothripsis is a mutational phenomenon characterized by massive, clustered genomic
rearrangements that occurs in cancer and other diseases. Recent studies in selected cancer …