L-selectin (CD62L) is a type-I transmembrane glycoprotein and cell adhesion molecule that
is expressed on most circulating leukocytes. Since its identification in 1983, L-selectin has …

Mucin type O‐glycosylation is one of the most diverse types of glycosylation, playing
essential roles in tissue development and homeostasis. In complex organisms, O‐GalNAc …

Mesenchymal stem cells (MSCs) are promising candidates for adult cell therapies in
regenerative medicine. To fully exert their potential, efficient homing and migration toward …

Neutrophil recruitment, lymphocyte recirculation and monocyte trafficking all require
adhesion and transmigration through blood-vessel walls. The traditional three steps of …

Reversible interactions of glycoconjugates on leukocytes with P-and E-selectin on
endothelial cells mediate tethering and rolling of leukocytes in inflamed vascular beds, the …

O-glycosylation is a highly frequent post-translation modification of proteins, with important
functional implications in both physiological and disease contexts. The biosynthesis of O …

Homeostatic regulation of neutrophil production is thought to match neutrophil elimination to
maintain approximately constant numbers in the blood. Here, we show that IL-17, a cytokine …

Glycosylation produces a diverse and abundant repertoire of glycans, which are collectively
known as the glycome. Glycans are one of the four fundamental macromolecular …

T-cell activation requires clustering of a threshold number of T-cell receptors (TCRs) at the
site of antigen presentation, a number that is reduced by CD28 co-receptor recruitment of …

Mucin-type O-glycans are a class of glycans initiated with N-acetylgalactosamine (GalNAc) α-
linked primarily to Ser/Thr residues within glycoproteins and often extended or branched by …