Inflammasomes are multiprotein innate immune complexes that regulate caspase-
dependent inflammation and cell death. Pattern recognition receptors, such as nucleotide …

Pyroptosis is a form of cell death mediated by gasdermin D (GSDMD); it is characterised by
NLRP3 inflammasome activation, caspase activation, cell membrane pore formation, and …

Diabetes mellitus is an extremely prevalent endocrine disease and a major global public
health concern. Diabetic complications, such as retinopathy, nephropathy, neuropathy and …

In the early 2000s, caspase-1, an important molecule that has been shown to be involved in
the regulation of inflammation, cell survival and diseases, was given a new function …

Diabetic nephropathy is a diabetic complication caused by chronic inflammation. As the
primary polyphenol in pomegranate, punicalagin is believed to have significant anti …

Pyroptosis is one special type of lytic programmed cell death, featured in cell swelling,
rupture, secretion of cell contents and remarkable proinflammation effect. In the process of …

It is now increasingly appreciated that inflammation is not limited to the control of pathogens
by the host, but rather that sterile inflammation which occurs in the absence of viral or …

Cytoplasmic nucleotide-binding oligomerization domain-like receptor protein 3 (NLRP3)
forms an inflammasome with apoptosis-associated speck-like protein containing a CARD …

The gut microbiota plays a pivotal role in the onset and development of diabetes and its
complications. Trimethylamine N-oxide (TMAO), a gut microbiota-dependent metabolite of …

NLRP3 (Nod-like receptor protein 3) belongs to the NOD-like receptor family, which is
activated by pathogen and damage-associated signals to form a multimeric protein complex …