MYC and KRAS cooperation: from historical challenges to therapeutic opportunities in cancer

S Casacuberta-Serra, Í González-Larreategui… - … and Targeted Therapy, 2024 - nature.com
RAS and MYC rank amongst the most commonly altered oncogenes in cancer, with RAS
being the most frequently mutated and MYC the most amplified. The cooperative interplay …

Colorectal cancer initiation: Understanding early-stage disease for intervention

C Jiang, Q Zhou, K Yi, Y Yuan, X Xie - Cancer Letters, 2024 - Elsevier
How tumors arise or the cause of precancerous lesions is a fundamental question in cancer
biology. It is generally accepted that tumors originate from normal cells that undergo …

Genome sequencing applications in precision medicine: From ancestry prediction to RNA variant calling

AE Bollas - 2024 - rave.ohiolink.edu
This dissertation focuses on advancing machine learning applications in genomic
sequencing, emphasizing the need for model transparency and reproducibility. We …