Obesity-induced changes in adipose tissue microenvironment and their impact on cardiovascular disease

JJ Fuster, N Ouchi, N Gokce, K Walsh - Circulation research, 2016 - Am Heart Assoc
Obesity is causally linked with the development of cardiovascular disorders. Accumulating
evidence indicates that cardiovascular disease is the collateral damage of obesity-driven …

Adipokines and proinflammatory cytokines, the key mediators in the pathogenesis of nonalcoholic fatty liver disease

S Stojsavljević, M Gomerčić Palčić… - World journal of …, 2014 - repozitorij.mef.unizg.hr
Nonalcoholic fatty liver disease (NAFLD) is a condition in which excess fat accumulates in
the liver of a patient with no history of alcohol abuse or other causes for secondary hepatic …

Adipokines and insulin resistance

K Rabe, M Lehrke, KG Parhofer, UC Broedl - Molecular medicine, 2008 - Springer
Obesity is associated with an array of health problems in adult and pediatric populations.
Understanding the pathogenesis of obesity and its metabolic sequelae has advanced …

Endocrine regulation of energy metabolism: review of pathobiochemical and clinical chemical aspects of leptin, ghrelin, adiponectin, and resistin

U Meier, AM Gressner - Clinical chemistry, 2004 - academic.oup.com
Background: Recent studies point to the adipose tissue as a highly active endocrine organ
secreting a range of hormones. Leptin, ghrelin, adiponectin, and resistin are considered to …

Resistin is an inflammatory marker of atherosclerosis in humans

MP Reilly, M Lehrke, ML Wolfe, A Rohatgi, MA Lazar… - Circulation, 2005 - Am Heart Assoc
Background—Resistin, a plasma protein, induces insulin resistance in rodents. Recent
reports suggest that circulating levels of resistin are elevated in obese and insulin-resistant …

Human resistin stimulates the pro-inflammatory cytokines TNF-α and IL-12 in macrophages by NF-κB-dependent pathway

N Silswal, AK Singh, B Aruna, S Mukhopadhyay… - Biochemical and …, 2005 - Elsevier
Resistin, a recently discovered 92 amino acid protein involved in the development of insulin
resistance, has been associated with obesity and type 2 diabetes. The elevated serum …

[PDF][PDF] Orlistat for overweight subjects with nonalcoholic steatohepatitis: a randomized, prospective trial

SA Harrison, W Fecht, EM Brunt… - …, 2009 - Wiley Online Library
The aim of this study was to determine if orlistat, an inhibitor of fat absorption, combined with
caloric restriction in overweight subjects with nonalcoholic steatohepatitis results in weight …

Resistin, adiponectin, ghrelin, leptin, and proinflammatory cytokines: relationships in obesity

J Vendrell, M Broch, N Vilarrasa, A Molina… - Obesity …, 2004 - Wiley Online Library
Objective: To evaluate interactions among leptin, adiponectin, resistin, ghrelin, and
proinflammatory cytokines [tumor necrosis factor receptors (TNFRs), interleukin‐6 (IL‐6)] in …

An update on metabolic syndrome: Metabolic risk markers and adipokines in the development of metabolic syndrome

R Kumari, S Kumar, R Kant - … & Metabolic Syndrome: Clinical Research & …, 2019 - Elsevier
Background Metabolic syndrome is a collection of physiological and biochemical
abnormalities about 20–25% of adult population in developing countries is suffering from …

An inflammatory cascade leading to hyperresistinemia in humans

M Lehrke, MP Reilly, SC Millington, N Iqbal… - PLoS …, 2004 - journals.plos.org
Background Obesity, the most common cause of insulin resistance, is increasingly
recognized as a low-grade inflammatory state. Adipocyte-derived resistin is a circulating …