The histone deacetylase (HDAC) enzymes, a class of epigenetic regulators, are historically
well established as attractive therapeutic targets. During investigation of trends within …

Genetic mutations and abnormal gene regulation are key mechanisms underlying
tumorigenesis. Nucleosomes, which consist of DNA wrapped around histone cores …

Abstract HDAC6, a class IIB HDAC isoenzyme, stands unique in its structural and
physiological functions. Besides histone modification, largely due to its cytoplasmic …

Histone deacetylases (HDACs) are enzymes that catalyze the removal of acetyl functional
groups from the lysine residues of both histone and nonhistone proteins. In humans, there …

Transcriptional regulation in eukaryotes occurs within a chromatin setting, and is strongly
influenced by the post-translational modification of histones, the building blocks of …

This article reviews the effects of the short-chain fatty acid butyrate on histone deacetylase
(HDAC) activity. Sodium butyrate has multiple effects on cultured mammalian cells that …

Histone deacetylases (HDACs) modify core histones and participate in large regulatory
complexes that both suppress and enhance transcription. Recent studies indicate that some …

Together, histone acetyltransferases and histone deacetylases (HDACs) determine the
acetylation status of histones. This acetylation affects the regulation of gene expression, and …

We have cloned and characterized a human cDNA that belongs to the histone deacetylase
family, which we designate as HDAC11. The predicted HDAC11 amino acid sequence …

Microtubules are cylindrical cytoskeletal structures found in almost all eukaryotic cell types
which are involved in a great variety of cellular processes. Reversible acetylation on the ϵ …