A developmental constraint model of cancer cell states and tumor heterogeneity
AS Patel, I Yanai - Cell, 2024 - cell.com
Cancer is a disease that stems from a fundamental liability inherent to multicellular life forms
in which an individual cell is capable of reneging on the interests of the collective organism …
in which an individual cell is capable of reneging on the interests of the collective organism …
Dissecting SOX2 expression and function reveals an association with multiple signaling pathways during embryonic development and in cancer progression
N Niharika, L Ureka, A Roy, SK Patra - Biochimica et Biophysica Acta (BBA) …, 2024 - Elsevier
Abstract SRY (Sex Determining Region) box 2 (SOX2) is an essential transcription factor that
plays crucial roles in activating genes involved in pre-and post-embryonic development …
plays crucial roles in activating genes involved in pre-and post-embryonic development …
Histone H4 asymmetrically dimethylated at arginine 3 (H4R3me2a), a mark of super-enhancers
SRN Sudhakar, L Wu, S Patel… - Biochemistry and Cell …, 2023 - cdnsciencepub.com
Histone H4 asymmetrically dimethylated at arginine 3 (H4R3me2a) is an active histone mark
catalyzed by protein arginine methyltransferase 1 (PRMT1), a major arginine …
catalyzed by protein arginine methyltransferase 1 (PRMT1), a major arginine …
[HTML][HTML] Possible Strategies to Reduce the Tumorigenic Risk of Reprogrammed Normal and Cancer Cells
YC Lin, CC Ku, K Wuputra, CJ Liu, DC Wu… - International Journal of …, 2024 - mdpi.com
The reprogramming of somatic cells to pluripotent stem cells has immense potential for use
in regenerating or redeveloping tissues for transplantation, and the future application of this …
in regenerating or redeveloping tissues for transplantation, and the future application of this …
The Multifaceted Role of SOX2 in Breast and Lung Cancer Dynamics
Breast and lung cancers are leading causes of death among patients, with their global
mortality and morbidity rates increasing. Conventional treatments often prove inadequate …
mortality and morbidity rates increasing. Conventional treatments often prove inadequate …
From sequence to consequence: Deciphering the complex cis-regulatory landscape
Cell type-specific expression of genes plays a pivotal role in the development and evolution
of multicellular organisms over millions of years. The majority of regulatory control resides …
of multicellular organisms over millions of years. The majority of regulatory control resides …
The Original M2 And M6 Mouse Models Of Glioblastoma: Morphological And Molecular Characteristics Of Transplanted Tumor Tissue
V Kudelkina, A Alekseeva, A Khalansky… - 2024 - preprints.org
Important tumor biomarkers, therapeutic targets, and mechanisms of tumorigenesis were
discovered in animal models. Mouse models of malignant gliomas were represented by …
discovered in animal models. Mouse models of malignant gliomas were represented by …