Mechanisms and pathology of protein misfolding and aggregation
Despite advances in machine learning-based protein structure prediction, we are still far
from fully understanding how proteins fold into their native conformation. The conventional …
from fully understanding how proteins fold into their native conformation. The conventional …
Half a century of amyloids: past, present and future
Amyloid diseases are global epidemics with profound health, social and economic
implications and yet remain without a cure. This dire situation calls for research into the …
implications and yet remain without a cure. This dire situation calls for research into the …
The microbiome as a modifier of neurodegenerative disease risk
The gut microbiome is increasingly implicated in modifying susceptibility to and progression
of neurodegenerative diseases (NDs). In this review, we discuss roles for the microbiome in …
of neurodegenerative diseases (NDs). In this review, we discuss roles for the microbiome in …
Biophysical processes underlying cross-seeding in amyloid aggregation and implications in amyloid pathology
MI Ivanova, Y Lin, YH Lee, J Zheng… - Biophysical chemistry, 2021 - Elsevier
Abnormal aggregation of proteins into filamentous aggregates commonly associates with
many diseases, such as Alzheimer's disease, Parkinson's disease and type-2 diabetes …
many diseases, such as Alzheimer's disease, Parkinson's disease and type-2 diabetes …
Amyloid cross-seeding: Mechanism, implication, and inhibition
Most neurodegenerative diseases such as Alzheimer's disease, type 2 diabetes, Parkinson's
disease, etc. are caused by inclusions and plaques containing misfolded protein …
disease, etc. are caused by inclusions and plaques containing misfolded protein …
Two decades of studying functional amyloids in microorganisms
In the past two decades, amyloids, typically associated with human diseases, have been
described to play various functional roles in nearly all life forms. The structural and functional …
described to play various functional roles in nearly all life forms. The structural and functional …
Fundamentals of cross-seeding of amyloid proteins: an introduction
Misfolded protein aggregates formed by the same (homologous) or different
(heterologous/cross) sequences are the pathological hallmarks of many protein misfolding …
(heterologous/cross) sequences are the pathological hallmarks of many protein misfolding …
[HTML][HTML] Upregulation of α-synuclein following immune activation: Possible trigger of Parkinson's disease
A Kasen, C Houck, AR Burmeister, Q Sha… - Neurobiology of …, 2022 - Elsevier
Abstract Alpha-synuclein (α-syn) has been suggested to have many functions including,
vesicle transport in neurons, transcriptional regulator, modulator of immune cell maturation …
vesicle transport in neurons, transcriptional regulator, modulator of immune cell maturation …
Functional amyloids from bacterial biofilms–structural properties and interaction partners
Ü Akbey, M Andreasen - Chemical Science, 2022 - pubs.rsc.org
Protein aggregation and amyloid formation have historically been linked with various
diseases such as Alzheimer's and Parkinson's disease, but recently functional amyloids …
diseases such as Alzheimer's and Parkinson's disease, but recently functional amyloids …
[HTML][HTML] Kynurenine pathway in Parkinson's disease—An update
D Venkatesan, M Iyer, A Narayanasamy, K Siva… - Eneurologicalsci, 2020 - Elsevier
Parkinson's disease (PD) is a complex multi-factorial neurodegenerative disorder where
various altered metabolic pathways contribute to the progression of the disease. Tryptophan …
various altered metabolic pathways contribute to the progression of the disease. Tryptophan …