[HTML][HTML] Methylation of RCAN1. 4 mediated by DNMT1 and DNMT3b enhances hepatic stellate cell activation and liver fibrogenesis through Calcineurin/NFAT3 …

X Pan, H You, L Wang, Y Bi, Y Yang, H Meng… - Theranostics, 2019 - ncbi.nlm.nih.gov
Background: Liver fibrosis is characterized by extensive deposition of extracellular matrix
(ECM) components in the liver. RCAN1 (regulator of calcineurin 1), an endogenous inhibitor …

Alterations in histone deacetylase 8 lead to cell migration and poor prognosis in breast cancer

CL Hsieh, HP Ma, CM Su, YJ Chang, WY Hung, YS Ho… - Life sciences, 2016 - Elsevier
Aims Alterations in histone proteins can lead to breast tumorigenesis. Selective histone
deacetylase 8 (HDAC8) inhibitors with fewer adverse effects have been developed. A more …

PINK1 positively regulates IL-1β-mediated signaling through Tollip and IRAK1 modulation

HJ Lee, KC Chung - Journal of neuroinflammation, 2012 - Springer
Background Parkinson disease (PD) is characterized by a slow, progressive degeneration of
dopaminergic neurons in the substantianigra. The cause of neuronal loss in PD is not well …

Leucine-rich repeat kinase 2 (LRRK2) stimulates IL-1β-mediated inflammatory signaling through phosphorylation of RCAN1

KA Han, L Yoo, JY Sung, SA Chung, JW Um… - Frontiers in cellular …, 2017 - frontiersin.org
Leucine-rich repeat kinase 2 (LRRK2) is a Ser/Thr kinase having mixed lineage kinase-like
and GTPase domains, controlling neurite outgrowth and neuronal cell death. Evidence …

Regulator of calcineurin 1 isoform 4 (RCAN1. 4) Is overexpressed in the glomeruli of diabetic mice

C Jang, JH Lim, CW Park… - The Korean Journal of …, 2011 - synapse.koreamed.org
Calcineurin (CaN) is activated in diabetes and plays a role in glomerular hypertrophy and
extracellular matrix (ECM) accumulation. Here, kidneys from diabetic model mice were …

Ubiquitin‐specific protease 22 (USP22) positively regulates RCAN1 protein levels through RCAN1 de‐ubiquitination

A Hong, JE Lee, KC Chung - Journal of cellular physiology, 2015 - Wiley Online Library
Protein ubiquitination can be reversed by de‐ubiquitinating enzymes (DUBs), which are
classified into two main classes, cysteine proteases and metalloproteases. Cysteine …

The Vertebrate RCAN Gene Family: Novel Insights into Evolution, Structure and Regulation

E Serrano-Candelas, D Farre, A Aranguren-Ibanez… - PLoS …, 2014 - journals.plos.org
Recently there has been much interest in the Regulators of Calcineurin (RCAN) proteins
which are important endogenous modulators of the calcineurin-NFATc signalling pathway …

Rcn1, the fission yeast homolog of human DSCR1, regulates arsenite tolerance independently from calcineurin

T Takasaki, A Bamba, Y Kukita, A Nishida… - Genes to …, 2024 - Wiley Online Library
Calcineurin (CN) is a conserved Ca2+/calmodulin‐dependent phosphoprotein phosphatase
that plays a key role in Ca2+ signaling. Regulator of calcineurin 1 (RCAN1), also known as …

Salmonella virulence factor SsrAB regulated factor modulates inflammatory responses by enhancing the activation of NF-κB signaling pathway

L Lei, W Wang, C Xia, F Liu - The Journal of Immunology, 2016 - journals.aai.org
Effector proteins encoded by Salmonella pathogenicity islands play a key role in promoting
bacterial intracellular survival, colonization, and pathogenesis. In this study, we investigated …

Covalent NEDD8 conjugation increases RCAN1 protein stability and potentiates its inhibitory action on calcineurin

EH Noh, HS Hwang, HS Hwang, B Min, E Im… - PloS one, 2012 - journals.plos.org
Similar to ubiquitin, regulatory roles for NEDD8 (neural precursor cell-expressed
developmentally down-regulated 8) are being clarified during cell growth, signal …