This article reviews what is presently known about the biological roles of the diet-derived
compound ergothioneine (ET). ET seems important to humans because it is rapidly taken up …

Vascular cognitive impairment (VCI) describes a wide spectrum of cognitive deficits related
to cerebrovascular diseases. Although the loss of blood flow to cortical regions critically …

Summary Low-molecular-weight (LMW) thiols are small-molecule antioxidants required for
the maintenance of intracellular redox homeostasis. However, many host-associated …

Alzheimer's Disease (AD) is a progressive neurodegenerative disease characterized by
amyloid-β (Aβ) plaque deposition and neurofibrillary tangle accumulation in the brain …

Healthy ageing is a crucial process that needs to be highlighted as it affects the quality of
lifespan. An increase in oxidative stress along with ageing is the major factor related to the …

Low blood concentrations of the diet-derived compound ergothioneine (ET) have been
associated with cognitive impairment and cerebrovascular disease (CeVD) in cross …

Abstract Ergothioneine, Ovothiol, and Selenoneine are sulfur/selenium-containing histidine-
derived natural products widely distributed across different organisms. They exhibit …

Age-associated cerebral small vessel disease (CSVD) represents a clinically heterogenous
condition, arising from diverse microvascular mechanisms. These lead to chronic …

We propose that the diet-derived compound ergothioneine (ET) is an important nutrient in
the human body, especially for maintenance of normal brain function, and that low body ET …

Oral administration of the food-derived antioxidant amino acid ergothioneine (ERGO) results
in its efficient distribution in the brain and enhances cognitive function. However, effect of …