By analyzing and simulating inactive conformations of the highly homologous dopamine D2
and D3 receptors (D2R and D3R), we find that eticlopride binds D2R in a pose very similar …

G protein-coupled receptors play essential roles in cellular processes such as neuronal
signaling, vision, olfaction, tasting, and metabolism. As GPCRs are the most important drug …

Background: Selectively targeting dopamine receptors (DRs) has been a persistent
challenge in the last years for the development of new treatments to combat the large variety …

Dopamine D2 receptors (D2R) are known to form transient homodimer complexes, of which
the increased formation has already been associated with development of schizophrenia …

Receptor-binding affinity and ligand-receptor residence time are key parameters for the
selection of drug candidates and are routinely determined using radioligand competition …

High and low sodium diets are associated with increased blood pressure and
cardiovascular morbidity and mortality. The paradoxical response of elevated BP in low salt …

Sodium ions (Na+) allosterically modulate the binding of orthosteric agonists and
antagonists to many class AG protein-coupled receptors, including the dopamine D2 …

Increasing evidence suggests that trace amine-associated receptor 1 (TAAR1) is an
important modulator of the dopaminergic system. Existing molecular evidence indicates that …

Perioperative anaphylaxis has a risk of mortality and compromised quality of patient care. It
is difficult to design an evaluation system for risk of anaphylaxis using preoperative tests …

Dopamine is a neurotransmitter essential to coordinate biochemical and behavioral
functions in the striatum by modulating dopamine receptor signaling, including the …