Osteoarthritis (OA) is the most well-known degenerative disease among the geriatric and is
a main cause of significant disability in daily living. It has a multifactorial etiology and is …

Acute nociceptive, inflammatory, and neuropathic pain all depend to some degree on the
peripheral activation of primary sensory afferent neurons. The localized peripheral …

This study characterizes the receptor subtypes and investigates some of the mechanisms by
which glutamate, injected intraplantarly (i. pl.) into the mouse paw, produces nociception …

The metabotropic glutamate receptors (mGluRs) are found throughout the central nervous
system, where they modulate neuronal excitability and synaptic transmission. Here we …

Chronic musculoskeletal pain is a major clinical problem and there is a general lack of
animal models to study this condition. Carrageenan is commonly used to produce short …

Animal studies have suggested that tissue injury–related increased levels of glutamate may
be involved in peripheral nociceptive mechanisms in deep craniofacial tissues. Indeed …

Peripheral inflammation induced with a knee joint injection of a mixture of
kaolin/carrageenan (k/c) produces primary and secondary hyperalgesia. Inflammatory pain …

In addition to using glutamate as a neurotransmitter at central synapses, many primary
sensory neurons release glutamate from peripheral terminals. Primary sensory neurons with …

The present study examined the effect of peripheral administration of the excitatory amino
acid (EAA) glutamate on the intensity of perceived pain and pressure pain thresholds (PPTs) …

Osteoarthritis is a chronic, inflammatory joint disease in the world. In India more than 20% of
total population is suffering from arthritis, although the main cause of disease is unknown …