Identification and consequences of miRNA–target interactions—beyond repression of gene expression
Comparative genomics analyses and high-throughput experimental studies indicate that a
microRNA (miRNA) binds to hundreds of sites across the transcriptome. Although the …
microRNA (miRNA) binds to hundreds of sites across the transcriptome. Although the …
MicroRNA functions in stress responses
AKL Leung, PA Sharp - Molecular cell, 2010 - cell.com
MicroRNAs (miRNAs) are a class of∼ 22 nucleotide short noncoding RNAs that play key
roles in fundamental cellular processes, including how cells respond to changes in …
roles in fundamental cellular processes, including how cells respond to changes in …
Comprehensive modeling of microRNA targets predicts functional non-conserved and non-canonical sites
Abstract mirSVR is a new machine learning method for ranking microRNA target sites by a
down-regulation score. The algorithm trains a regression model on sequence and …
down-regulation score. The algorithm trains a regression model on sequence and …
Mechanisms of dendritic mRNA transport and its role in synaptic tagging
M Doyle, MA Kiebler - The EMBO journal, 2011 - embopress.org
The localization of RNAs critically contributes to many important cellular processes in an
organism, such as the establishment of polarity, asymmetric division and migration during …
organism, such as the establishment of polarity, asymmetric division and migration during …
The regulation of mRNA stability in mammalian cells: 2.0
X Wu, G Brewer - Gene, 2012 - Elsevier
Messenger RNA decay is an essential step in gene expression to set mRNA abundance in
the cytoplasm. The binding of proteins and/or noncoding RNAs to specific recognition …
the cytoplasm. The binding of proteins and/or noncoding RNAs to specific recognition …
[HTML][HTML] SNHG16 is regulated by the Wnt pathway in colorectal cancer and affects genes involved in lipid metabolism
LL Christensen, K True, MP Hamilton, MM Nielsen… - Molecular …, 2016 - Elsevier
It is well established that lncRNAs are aberrantly expressed in cancer where they have been
shown to act as oncogenes or tumor suppressors. RNA profiling of 314 colorectal …
shown to act as oncogenes or tumor suppressors. RNA profiling of 314 colorectal …
MicroRNA-449 and microRNA-34b/c function redundantly in murine testes by targeting E2F transcription factor-retinoblastoma protein (E2F-pRb) pathway
MicroRNAs (miRNAs) mainly function as post-transcriptional regulators and are involved in
a wide range of physiological and pathophysiological processes such as cell proliferation …
a wide range of physiological and pathophysiological processes such as cell proliferation …
miR-449 inhibits cell proliferation and is down-regulated in gastric cancer
T Bou Kheir, E Futoma-Kazmierczak, A Jacobsen… - Molecular cancer, 2011 - Springer
Background Gastric cancer is the fourth most common cancer in the world and the second
most prevalent cause of cancer related death. The development of gastric cancer is mainly …
most prevalent cause of cancer related death. The development of gastric cancer is mainly …
Analysis of microRNA-target interactions across diverse cancer types
A Jacobsen, J Silber, G Harinath, JT Huse… - Nature structural & …, 2013 - nature.com
Little is known about the extent to which individual microRNAs (miRNAs) regulate common
processes of tumor biology across diverse cancer types. Using molecular profiles of> 3,000 …
processes of tumor biology across diverse cancer types. Using molecular profiles of> 3,000 …
TGF-β induces miR-100 and miR-125b but blocks let-7a through LIN28B controlling PDAC progression
TGF-β/Activin induces epithelial-to-mesenchymal transition and stemness in pancreatic
ductal adenocarcinoma (PDAC). However, the microRNAs (miRNAs) regulated during this …
ductal adenocarcinoma (PDAC). However, the microRNAs (miRNAs) regulated during this …