Lessons in self-defence: inhibition of virus entry by intrinsic immunity

S Majdoul, AA Compton - Nature Reviews Immunology, 2022 - nature.com
Virus entry, consisting of attachment to and penetration into the host target cell, is the first
step of the virus life cycle and is a critical 'do or die'event that governs virus emergence in …

[HTML][HTML] Evasion of host immune defenses by human papillomavirus

JA Westrich, CJ Warren, D Pyeon - Virus research, 2017 - Elsevier
A majority of human papillomavirus (HPV) infections are asymptomatic and self-resolving in
the absence of medical interventions. Various innate and adaptive immune responses, as …

Syncytia formation by SARS‐CoV‐2‐infected cells

J Buchrieser, J Dufloo, M Hubert, B Monel… - The EMBO …, 2020 - embopress.org
Severe cases of COVID‐19 are associated with extensive lung damage and the presence of
infected multinucleated syncytial pneumocytes. The viral and cellular mechanisms …

IFITM3 directly engages and shuttles incoming virus particles to lysosomes

JS Spence, R He, HH Hoffmann, T Das… - Nature chemical …, 2019 - nature.com
Interferon-induced transmembrane proteins (IFITMs 1, 2 and 3) have emerged as important
innate immune effectors that prevent diverse virus infections in vertebrates. However, the …

APOBEC3A functions as a restriction factor of human papillomavirus

CJ Warren, T Xu, K Guo, LM Griffin, JA Westrich… - Journal of …, 2015 - Am Soc Microbiol
Human papillomaviruses (HPVs) are small DNA viruses causally associated with benign
warts and multiple cancers, including cervical and head-and-neck cancers. While the vast …

Identification of residues controlling restriction versus enhancing activities of IFITM proteins on entry of human coronaviruses

X Zhao, M Sehgal, Z Hou, J Cheng, S Shu… - Journal of …, 2018 - Am Soc Microbiol
Interferon-induced transmembrane proteins (IFITMs) are restriction factors that inhibit the
infectious entry of many enveloped RNA viruses. However, we demonstrated previously that …

IFITM proteins inhibit entry driven by the MERS-coronavirus spike protein: evidence for cholesterol-independent mechanisms

F Wrensch, M Winkler, S Pöhlmann - Viruses, 2014 - mdpi.com
The interferon-inducible transmembrane (IFITM) proteins 1, 2 and 3 inhibit the host cell entry
of several enveloped viruses, potentially by promoting the accumulation of cholesterol in …

IFITM protein regulation and functions: Far beyond the fight against viruses

N Friedlová, F Zavadil Kokáš, TR Hupp… - Frontiers in …, 2022 - frontiersin.org
Interferons (IFNs) are important cytokines that regulate immune responses through the
activation of hundreds of genes, including interferon-induced transmembrane proteins …

[HTML][HTML] Roles of APOBEC3A and APOBEC3B in human papillomavirus infection and disease progression

CJ Warren, JA Westrich, KV Doorslaer, D Pyeon - Viruses, 2017 - mdpi.com
The apolipoprotein B messenger RNA-editing, enzyme-catalytic, polypeptide-like 3
(APOBEC3) family of cytidine deaminases plays an important role in the innate immune …

Lipid interactions during virus entry and infection

M Mazzon, J Mercer - Cellular microbiology, 2014 - Wiley Online Library
For entry and infection viruses have developed numerous strategies to subjugate
indispensable cellular factors and functions. Host cell lipids and cellular lipid synthesis …