Lessons in self-defence: inhibition of virus entry by intrinsic immunity
S Majdoul, AA Compton - Nature Reviews Immunology, 2022 - nature.com
Virus entry, consisting of attachment to and penetration into the host target cell, is the first
step of the virus life cycle and is a critical 'do or die'event that governs virus emergence in …
step of the virus life cycle and is a critical 'do or die'event that governs virus emergence in …
[HTML][HTML] Evasion of host immune defenses by human papillomavirus
A majority of human papillomavirus (HPV) infections are asymptomatic and self-resolving in
the absence of medical interventions. Various innate and adaptive immune responses, as …
the absence of medical interventions. Various innate and adaptive immune responses, as …
Syncytia formation by SARS‐CoV‐2‐infected cells
J Buchrieser, J Dufloo, M Hubert, B Monel… - The EMBO …, 2020 - embopress.org
Severe cases of COVID‐19 are associated with extensive lung damage and the presence of
infected multinucleated syncytial pneumocytes. The viral and cellular mechanisms …
infected multinucleated syncytial pneumocytes. The viral and cellular mechanisms …
IFITM3 directly engages and shuttles incoming virus particles to lysosomes
Interferon-induced transmembrane proteins (IFITMs 1, 2 and 3) have emerged as important
innate immune effectors that prevent diverse virus infections in vertebrates. However, the …
innate immune effectors that prevent diverse virus infections in vertebrates. However, the …
APOBEC3A functions as a restriction factor of human papillomavirus
Human papillomaviruses (HPVs) are small DNA viruses causally associated with benign
warts and multiple cancers, including cervical and head-and-neck cancers. While the vast …
warts and multiple cancers, including cervical and head-and-neck cancers. While the vast …
Identification of residues controlling restriction versus enhancing activities of IFITM proteins on entry of human coronaviruses
Interferon-induced transmembrane proteins (IFITMs) are restriction factors that inhibit the
infectious entry of many enveloped RNA viruses. However, we demonstrated previously that …
infectious entry of many enveloped RNA viruses. However, we demonstrated previously that …
IFITM proteins inhibit entry driven by the MERS-coronavirus spike protein: evidence for cholesterol-independent mechanisms
F Wrensch, M Winkler, S Pöhlmann - Viruses, 2014 - mdpi.com
The interferon-inducible transmembrane (IFITM) proteins 1, 2 and 3 inhibit the host cell entry
of several enveloped viruses, potentially by promoting the accumulation of cholesterol in …
of several enveloped viruses, potentially by promoting the accumulation of cholesterol in …
IFITM protein regulation and functions: Far beyond the fight against viruses
N Friedlová, F Zavadil Kokáš, TR Hupp… - Frontiers in …, 2022 - frontiersin.org
Interferons (IFNs) are important cytokines that regulate immune responses through the
activation of hundreds of genes, including interferon-induced transmembrane proteins …
activation of hundreds of genes, including interferon-induced transmembrane proteins …
[HTML][HTML] Roles of APOBEC3A and APOBEC3B in human papillomavirus infection and disease progression
The apolipoprotein B messenger RNA-editing, enzyme-catalytic, polypeptide-like 3
(APOBEC3) family of cytidine deaminases plays an important role in the innate immune …
(APOBEC3) family of cytidine deaminases plays an important role in the innate immune …
Lipid interactions during virus entry and infection
For entry and infection viruses have developed numerous strategies to subjugate
indispensable cellular factors and functions. Host cell lipids and cellular lipid synthesis …
indispensable cellular factors and functions. Host cell lipids and cellular lipid synthesis …