Higher mortality of COVID-19 in males: sex differences in immune response and cardiovascular comorbidities
LA Bienvenu, J Noonan, X Wang… - Cardiovascular …, 2020 - academic.oup.com
The high mortality rate of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2)
infection is a critical concern of the coronavirus disease 2019 (COVID-19) pandemic …
infection is a critical concern of the coronavirus disease 2019 (COVID-19) pandemic …
The impact of estrogens and their receptors on immunity and inflammation during infection
AT Harding, NS Heaton - Cancers, 2022 - mdpi.com
Simple Summary Human health is significantly affected by microbial infections. One of the
largest determinants of the outcomes of such infections is the host immune response. Too …
largest determinants of the outcomes of such infections is the host immune response. Too …
Endocrine factors modulating immune responses in pregnancy
A Schumacher, SD Costa, AC Zenclussen - Frontiers in immunology, 2014 - frontiersin.org
How the semi-allogeneic fetus is tolerated by the maternal immune system remains a
fascinating phenomenon. Despite extensive research activity in this field, the mechanisms …
fascinating phenomenon. Despite extensive research activity in this field, the mechanisms …
17β-estradiol protects females against influenza by recruiting neutrophils and increasing virus-specific CD8 T cell responses in the lungs
DP Robinson, OJ Hall, TL Nilles, JH Bream… - Journal of …, 2014 - Am Soc Microbiol
ABSTRACT 17β-Estradiol (E2) treatment limits the pathology associated with pulmonary
diseases caused by pathogens, allergens, and asthma, partly by reducing the production of …
diseases caused by pathogens, allergens, and asthma, partly by reducing the production of …
H1N1 influenza virus infection results in adverse pregnancy outcomes by disrupting tissue-specific hormonal regulation
Increased susceptibility to influenza virus infection during pregnancy has been attributed to
immunological changes occurring before and during gestation in order to “tolerate” the …
immunological changes occurring before and during gestation in order to “tolerate” the …
Influenza pathogenesis: the effect of host factors on severity of disease
AP Gounder, A Boon - The journal of immunology, 2019 - journals.aai.org
Influenza viruses continue to be a major global health threat. Severity and clinical outcome
of influenza disease is determined by both viral and host factors. Viral factors have long …
of influenza disease is determined by both viral and host factors. Viral factors have long …
The intersection of sex and gender in the treatment of influenza
Highlights•Males and females differ in the outcome of influenza A virus (IAV) infections,
which depends significantly on age.•Inflammatory immune responses and repair of …
which depends significantly on age.•Inflammatory immune responses and repair of …
Role of inflammation in virus pathogenesis during pregnancy
Viral infections during pregnancy lead to a spectrum of maternal and fetal outcomes, ranging
from asymptomatic disease to more critical conditions presenting with severe maternal …
from asymptomatic disease to more critical conditions presenting with severe maternal …
Pathogenesis of viral infections during pregnancy
PS Creisher, SL Klein - Clinical Microbiology Reviews, 2024 - Am Soc Microbiol
Viral infections during pregnancy are associated with significant adverse perinatal and fetal
outcomes. Pregnancy is a unique immunologic and physiologic state, which can influence …
outcomes. Pregnancy is a unique immunologic and physiologic state, which can influence …
GPER1 is required to protect fetal health from maternal inflammation
Type I interferon (IFN) signaling in fetal tissues causes developmental abnormalities and
fetal demise. Although pathogens that infect fetal tissues can induce birth defects through …
fetal demise. Although pathogens that infect fetal tissues can induce birth defects through …