Targeted transitions in chromatin states at thousands of genes are essential drivers of
eukaryotic development. Therefore, understanding the in vivo dynamics of epigenetic …

Hox transcription factors (TFs) function as key determinants in the specification of cell fates
during development. They do so by triggering entire morphogenetic cascades through the …

Tissue homeostasis requires long-term lineage fidelity of somatic stem cells. Whether and
how age-related changes in somatic stem cells impact the faithful execution of lineage …

Polycomb-group proteins are conserved chromatin factors that maintain the silencing of key
developmental genes, notably the Hox gene clusters, outside of their expression domains …

Exhaustion of stem cells is a hallmark of aging. In the Drosophila testis, dedifferentiated
germline stem cells (GSCs) derived from spermatogonia increase during lifespan, leading to …

The success of neopteran insects, with 1 million species described, is associated with
developmental innovations such as holometaboly and the evolution from short to long …

Hox genes, specifically the bithorax complex (ubx, abdominal-a, and abdominal-b), play a
crucial role in specifying posterior abdominal development and serve as key regulators of …

Epithelial fusion establishes continuity between the separated flanks of epithelial sheets.
Despite its importance in creating resilient barriers, the mechanisms that ensure stable …

Colorectal cancer ranks third in terms of incidence and second in terms of mortality
worldwide. The homeobox transcript antisense intergenic RNA (HOTAIR), which was found …

Epithelial fusion establishes continuity between the separated flanks of epithelial sheets.
Despite its importance in creating resilient barriers, the mechanisms that ensure stable …