The physiology, pathology, and pharmacology of voltage-gated calcium channels and their future therapeutic potential
GW Zamponi, J Striessnig, A Koschak… - Pharmacological …, 2015 - Elsevier
Voltage-gated calcium channels are required for many key functions in the body. In this
review, the different subtypes of voltage-gated calcium channels are described and their …
review, the different subtypes of voltage-gated calcium channels are described and their …
Calcium channel auxiliary α2δ and β subunits: trafficking and one step beyond
AC Dolphin - Nature Reviews Neuroscience, 2012 - nature.com
The voltage-gated calcium channel α2δ and β subunits are traditionally considered to be
auxiliary subunits that enhance channel trafficking, increase the expression of functional …
auxiliary subunits that enhance channel trafficking, increase the expression of functional …
[HTML][HTML] The α2δ subunits of voltage-gated calcium channels
AC Dolphin - Biochimica et Biophysica Acta (BBA)-Biomembranes, 2013 - Elsevier
Voltage-gated calcium channels consist of the main pore-forming α1 subunit, together,
except in the case of the T-type channels, with β and α2δ and sometimes γ subunits, which …
except in the case of the T-type channels, with β and α2δ and sometimes γ subunits, which …
[HTML][HTML] HDAC4 governs a transcriptional program essential for synaptic plasticity and memory
Neuronal activity influences genes involved in circuit development and information
processing. However, the molecular basis of this process remains poorly understood. We …
processing. However, the molecular basis of this process remains poorly understood. We …
Bassoon specifically controls presynaptic P/Q-type Ca2+ channels via RIM-binding protein
D Davydova, C Marini, C King, J Klueva, F Bischof… - Neuron, 2014 - cell.com
Summary Voltage-dependent Ca 2+ channels (Ca V s) represent the principal source of Ca
2+ ions that trigger evoked neurotransmitter release from presynaptic boutons. Ca 2+ influx …
2+ ions that trigger evoked neurotransmitter release from presynaptic boutons. Ca 2+ influx …
Excitatory motor neurons are local oscillators for backward locomotion
Cell-or network-driven oscillators underlie motor rhythmicity. The identity of C. elegans
oscillators remains unknown. Through cell ablation, electrophysiology, and calcium imaging …
oscillators remains unknown. Through cell ablation, electrophysiology, and calcium imaging …
Retrograde synaptic inhibition is mediated by α-neurexin binding to the α2δ subunits of N-type calcium channels
The synaptic adhesion molecules Neurexin and Neuroligin alter the development and
function of synapses and are linked to autism in humans. In C. elegans, post-synaptic …
function of synapses and are linked to autism in humans. In C. elegans, post-synaptic …
Calcium channel functions in pain processing
J Park, ZD Luo - Channels, 2010 - Taylor & Francis
Voltage-gated calcium channels (VGCC) play obligatory physiological roles, including
modulation of neuronal functions, synaptic plasticity, neurotransmitter release and gene …
modulation of neuronal functions, synaptic plasticity, neurotransmitter release and gene …
Constitutive XBP-1s-mediated activation of the endoplasmic reticulum unfolded protein response protects against pathological tau
SM Waldherr, TJ Strovas, TA Vadset… - Nature …, 2019 - nature.com
To endure over the organismal lifespan, neurons utilize multiple strategies to achieve
protein homeostasis (proteostasis). Some homeostatic mechanisms act in a subcellular …
protein homeostasis (proteostasis). Some homeostatic mechanisms act in a subcellular …
The functional organization of motor nerve terminals
CR Slater - Progress in neurobiology, 2015 - Elsevier
Neuromuscular junctions (NMJs) have long been studied as particularly accessible
examples of chemical synapses. Nonetheless, some important features of neuromuscular …
examples of chemical synapses. Nonetheless, some important features of neuromuscular …