The physiology, pathology, and pharmacology of voltage-gated calcium channels and their future therapeutic potential

GW Zamponi, J Striessnig, A Koschak… - Pharmacological …, 2015 - Elsevier
Voltage-gated calcium channels are required for many key functions in the body. In this
review, the different subtypes of voltage-gated calcium channels are described and their …

Calcium channel auxiliary α2δ and β subunits: trafficking and one step beyond

AC Dolphin - Nature Reviews Neuroscience, 2012 - nature.com
The voltage-gated calcium channel α2δ and β subunits are traditionally considered to be
auxiliary subunits that enhance channel trafficking, increase the expression of functional …

[HTML][HTML] The α2δ subunits of voltage-gated calcium channels

AC Dolphin - Biochimica et Biophysica Acta (BBA)-Biomembranes, 2013 - Elsevier
Voltage-gated calcium channels consist of the main pore-forming α1 subunit, together,
except in the case of the T-type channels, with β and α2δ and sometimes γ subunits, which …

[HTML][HTML] HDAC4 governs a transcriptional program essential for synaptic plasticity and memory

R Sando, N Gounko, S Pieraut, L Liao, J Yates… - Cell, 2012 - cell.com
Neuronal activity influences genes involved in circuit development and information
processing. However, the molecular basis of this process remains poorly understood. We …

Bassoon specifically controls presynaptic P/Q-type Ca2+ channels via RIM-binding protein

D Davydova, C Marini, C King, J Klueva, F Bischof… - Neuron, 2014 - cell.com
Summary Voltage-dependent Ca 2+ channels (Ca V s) represent the principal source of Ca
2+ ions that trigger evoked neurotransmitter release from presynaptic boutons. Ca 2+ influx …

Excitatory motor neurons are local oscillators for backward locomotion

S Gao, SA Guan, AD Fouad, J Meng, T Kawano… - Elife, 2018 - elifesciences.org
Cell-or network-driven oscillators underlie motor rhythmicity. The identity of C. elegans
oscillators remains unknown. Through cell ablation, electrophysiology, and calcium imaging …

Retrograde synaptic inhibition is mediated by α-neurexin binding to the α2δ subunits of N-type calcium channels

XJ Tong, EJ López-Soto, L Li, H Liu, D Nedelcu… - Neuron, 2017 - cell.com
The synaptic adhesion molecules Neurexin and Neuroligin alter the development and
function of synapses and are linked to autism in humans. In C. elegans, post-synaptic …

Calcium channel functions in pain processing

J Park, ZD Luo - Channels, 2010 - Taylor & Francis
Voltage-gated calcium channels (VGCC) play obligatory physiological roles, including
modulation of neuronal functions, synaptic plasticity, neurotransmitter release and gene …

Constitutive XBP-1s-mediated activation of the endoplasmic reticulum unfolded protein response protects against pathological tau

SM Waldherr, TJ Strovas, TA Vadset… - Nature …, 2019 - nature.com
To endure over the organismal lifespan, neurons utilize multiple strategies to achieve
protein homeostasis (proteostasis). Some homeostatic mechanisms act in a subcellular …

The functional organization of motor nerve terminals

CR Slater - Progress in neurobiology, 2015 - Elsevier
Neuromuscular junctions (NMJs) have long been studied as particularly accessible
examples of chemical synapses. Nonetheless, some important features of neuromuscular …