Three decades of research on angiogenin: a review and perspective

J Sheng, Z Xu - Acta Biochim Biophys Sin, 2016 - academic.oup.com
As a member of the vertebrate-specific secreted ribonucleases, angiogenin (ANG) was first
isolated and identified solely by its ability to induce new blood vessel formation, and now, it …

G-quadruplex structures contribute to the neuroprotective effects of angiogenin-induced tRNA fragments

P Ivanov, E O'Day, MM Emara… - Proceedings of the …, 2014 - National Acad Sciences
Angiogenin (ANG) is a stress-activated ribonuclease that promotes the survival of motor
neurons. Ribonuclease inactivating point mutations are found in a subset of patients with …

Osteoclasts protect bone blood vessels against senescence through the angiogenin/plexin-B2 axis

X Liu, Y Chai, G Liu, W Su, Q Guo, X Lv, P Gao… - Nature …, 2021 - nature.com
Synthetic glucocorticoids (GCs), one of the most effective treatments for chronic inflammatory
and autoimmune conditions in children, have adverse effects on the growing skeleton. GCs …

Angiogenin-cleaved tRNA halves interact with cytochrome c, protecting cells from apoptosis during osmotic stress

M Saikia, R Jobava, M Parisien, A Putnam… - … and cellular biology, 2014 - Am Soc Microbiol
Adaptation to changes in extracellular tonicity is essential for cell survival. However, severe
or chronic hyperosmotic stress induces apoptosis, which involves cytochrome c (Cyt c) …

Senescent cells limit p53 activity via multiple mechanisms to remain viable

I Sturmlechner, CC Sine, KB Jeganathan… - Nature …, 2022 - nature.com
Super-enhancers regulate genes with important functions in processes that are cell type-
specific or define cell identity. Mouse embryonic fibroblasts establish 40 senescence …

Molecular Biology of Human Herpesvirus 8: Novel Functions and Virus–Host Interactions Implicated in Viral Pathogenesis and Replication

E Cousins, J Nicholas - Viruses and Human Cancer: From Basic Science …, 2014 - Springer
Abstract Human herpesvirus 8 (HHV-8), also known as Kaposi's sarcoma-associated
herpesvirus (KSHV), is the second identified human gammaherpesvirus. Like its relative …

Molecular and clinical characterization of ANG expression in gliomas and its association with tumor-related immune response

J Wang, A Shan, F Shi, Q Zheng - Frontiers in Medicine, 2023 - frontiersin.org
Background Angiogenin (ANG) has been widely reported as a crucial molecular regulator in
multiple malignancies. However, its role in gliomagenesis remains unclear. This study …

[HTML][HTML] Regulation of lung injury and fibrosis by p53-mediated changes in urokinase and plasminogen activator inhibitor-1

YP Bhandary, SK Shetty, AS Marudamuthu… - The American journal of …, 2013 - Elsevier
Alveolar type II epithelial cell (ATII) apoptosis and proliferation of mesenchymal cells are the
hallmarks of idiopathic pulmonary fibrosis, a devastating disease of unknown cause …

[HTML][HTML] Angiogenin interacts with the plasminogen activation system at the cell surface of breast cancer cells to regulate plasmin formation and cell migration

S Dutta, C Bandyopadhyay, V Bottero, MV Veettil… - Molecular …, 2014 - Elsevier
Abstract Angiogenin (ANG), a 14-kDa pro-angiogenic secreted protein, has been shown to
play a role in cell migration and tumor invasion, which involve proteolytic cleavage of …

Overexpression of angiogenin in pterygium body fibroblasts and its association with proliferative potency

KW Kim, SH Park, SW Wee… - … ophthalmology & visual …, 2013 - iovs.arvojournals.org
Purpose.: Angiogenin (ANG) originally was identified as an angiogenic tumor factor, and
recently its biologic activity is extended to stimulating cell proliferation. With viewing …