Macropinocytosis is a regulated form of endocytosis that mediates the non‐selective uptake
of solute molecules, nutrients and antigens. It is an actin‐dependent process initiated from …

Phosphoinositide 3-kinases (PI3Ks) control many important aspects of immune cell
development, differentiation, and function. Mammals have eight PI3K catalytic subunits that …

Mammalian two-pore channel proteins (TPC1, TPC2; TPCN1, TPCN2) encode ion channels
in intracellular endosomes and lysosomes and were proposed to mediate endolysosomal …

Endocytosis, phagocytosis, and macropinocytosis are fundamental processes that enable
cells to sample their environment, eliminate pathogens and apoptotic bodies, and regulate …

Macropinocytosis is defined as an actin-dependent but coat-and dynamin-independent
endocytic uptake process, which generates large intracellular vesicles (macropinosomes) …

Following phagocytosis, the nascent phagosome undergoes maturation to become a
phagolysosome with an acidic, hydrolytic, and often oxidative lumen that can efficiently kill …

The mammalian genome encodes 49 proteins that possess a PX (phox-homology) domain,
responsible for membrane attachment to organelles of the secretory and endocytic system …

The retromer is a trimeric cargo‐recognition protein complex composed of Vps26, Vps29
and Vps35 associated with protein trafficking within endosomes. Recently, a pathogenic …

Phosphoinositide signaling lipids (PIPs) are key regulators of membrane identity and
trafficking. Of these, PI (3, 5) P2 is one of the least well-understood, despite key roles in …

Recent studies of the low abundant signaling lipid, phosphatidylinositol 3, 5‐bisphosphate
(PI (3, 5) P2), reveal an intriguingly diverse list of downstream pathways, the intertwined …