Recent advances in isoxazole chemistry

AV Galenko, AF Khlebnikov, MS Novikov… - Russian Chemical …, 2015 - iopscience.iop.org
The preparation methods and reactions of isoxazoles are described and systematized on
the basis of analysis of the literature published from 2005 to present. In the discussion of …

Discovery, development, chemical diversity and design of isoxazoline-based insecticides

IL Gonçalves, GM das Neves, LP Kagami… - Bioorganic & Medicinal …, 2021 - Elsevier
Isoxazoline is a 5-membered heterocycle present in the active compounds of many
commercial veterinary anti-ectoparasitic products. The molecular target of isoxazolines is the …

Synthesis of new isoxazoline derivatives from harmine and evaluation of their anti-Alzheimer, anti-cancer and anti-inflammatory activities

I Filali, J Bouajila, M Znati… - Journal of enzyme …, 2015 - Taylor & Francis
In our study, a series of new harmine derivatives has been prepared by cycloaddition
reaction using various arylnitrile oxides and evaluated in vitro against acetylcholinesterase …

Local nucleophile-electrophile interactions in [3+ 2] cycloaddition reactions between benzonitrile N-oxide and selected conjugated nitroalkenes in the light of MEDT …

K Kula, K Zawadzińska - Current Chemistry Letters, 2021 - growingscience.com
The regioselectivity of the [3+ 2] cycloaddition reactions between benzonitrile N-oxide as
three-atom component and two series of para-substituted β-nitrostyrene analogues was …

Nitrile Oxide, Alkenes, Dipolar Cycloaddition, Isomerization and Metathesis Involved in the Syntheses of 2-Isoxazolines

S Krompiec, P Lodowski, A Kurpanik-Wójcik, B Gołek… - Molecules, 2023 - mdpi.com
The involvement of 1, 3-dipolar cycloaddition (1, 3-DP), double bond migration, metathesis,
and nitrile oxide (including in situ-generated nitrile oxide) as dipoles, together with the C= C …

Conversion of aldoximes into nitriles and amides under mild conditions

K Tambara, GD Pantoş - Organic & Biomolecular Chemistry, 2013 - pubs.rsc.org
A series of Pd (en) X2 salts were used as catalysts for the conversion of aldoximes into
nitriles and amides. Highlights of this protocol include the use of inexpensive polar solvents …

TEMPO‐Mediated Selective Synthesis of Isoxazolines, 5‐Hydroxy‐2‐isoxazolines, and Isoxazoles via Aliphatic δ‐C(sp3)‐H Bond Oxidation of Oximes

S Mondal, S Biswas, KG Ghosh… - Chemistry–An Asian …, 2021 - Wiley Online Library
Selective synthesis of three different bioactive heterocycles; isoxazolines, 5‐hydroxy‐2‐
isoxazolines and isoxazoles from the same starting material using TEMPO (2, 2, 6, 6 …

Selenides and diselenides containing oxadiazoles: a new class of functionalised materials

TE Frizon, DS Rampon, H Gallardo, AA Merlo… - Liquid …, 2012 - Taylor & Francis
A simple and efficient procedure for the synthesis of a new class of organoselenium liquid
crystal compounds was developed. The coupling of aryl bromides with elemental selenium …

Synthesis of benzalacetophenone-based isoxazoline and isoxazole derivatives

S Farooq, Z Ngaini - Current Organic Chemistry, 2022 - ingentaconnect.com
The demand for natural product-based drugs with less cost and efficient procedures has
become a challenge for researchers. Benzalacetophenone is a natural product-based …

Isoxazoline-and isoxazole-liquid crystalline schiff bases: A puzzling game dictated by entropy and enthalpy effects

L Fritsch, LA Baptista, IH Bechtold, G Araujo… - Journal of Molecular …, 2020 - Elsevier
Two series of Schiff base (SB) liquid crystals (LC) containing the 5-membered rings
isoxazoline or isoxazole were synthesized and characterized; 27 isoxazoline and 20 …