The historical development of the cell death concept is reviewed, with special attention to the
origin of the terms necrosis, coagulation necrosis, autolysis, physiological cell death …

Regardless of whether apoptosis or necrosis are elicited by toxicants or by
pathophysiological conditions they are considered conceptually distinct forms of cell death …

Although 13 years have passed since identification of human immunodeficiency virus-1 (HIV-
1) as the cause of AIDS, we do not yet know how HIV kills its primary target, the T cell that …

To the breast-fed infant, human milk is more than a source of nutrients; it furnishes a wide
array of molecules that restrict microbes, such as antibodies, bactericidins, and inhibitors of …

This study sought evidence for apoptosis, a form of programmed cell death, in human
atheromatous coronary and carotid arteries. Markers for apoptotic cells included in situ …

Mice deficient for the major lysosomal aspartic proteinase cathepsin D, generated by gene
targeting, develop normally during the first 2 weeks, stop thriving in the third week and die in …

OBJECTIVES: The study aims were to conclusively demonstrate apoptosis in the human
placenta and to quantify its incidence at different stages of pregnancy. STUDY DESIGN …

c‐Jun, a signal‐transducing transcription factor of the AP‐1 family, normally implicated in
cell cycle progression, differentiation and cell transformation, recently has also been linked …

OBJECTIVES: Our purpose was to investigate a possible role for apoptosis in the
pathophysiologic mechanisms of intrauterine growth restriction. STUDY DESIGN: Placental …

Apoptosis occurs in the normal liver and in various forms of liver disease. The CD95 (APO-
1/Fas)(CD95) receptor mediates apoptosis, and liver cells in animal models are acutely …