Microbiota-derived metabolites as drivers of gut–brain communication

H Ahmed, Q Leyrolle, V Koistinen, O Kärkkäinen… - Gut …, 2022 - Taylor & Francis
Alterations in the gut microbiota composition have been associated with a range of
neurodevelopmental, neurodegenerative, and neuropsychiatric disorders. The gut microbes …

Early-life interactions between the microbiota and immune system: impact on immune system development and atopic disease

K Donald, BB Finlay - Nature Reviews Immunology, 2023 - nature.com
Prenatal and early postnatal life represent key periods of immune system development. In
addition to genetics and host biology, environment has a large and irreversible role in the …

[HTML][HTML] Understanding the role of the gut microbiome in brain development and its association with neurodevelopmental psychiatric disorders

S Dash, YA Syed, MR Khan - Frontiers in Cell and Developmental …, 2022 - frontiersin.org
The gut microbiome has a tremendous influence on human physiology, including the
nervous system. During fetal development, the initial colonization of the microbiome …

[HTML][HTML] Diet-and microbiota-related metabolite, 5-aminovaleric acid betaine (5-AVAB), in health and disease

R Haikonen, O Kärkkäinen, V Koistinen… - Trends in Endocrinology …, 2022 - cell.com
5-Aminovaleric acid betaine (5-AVAB) is a trimethylated compound associated with the gut
microbiota, potentially produced endogenously, and related to the dietary intake of certain …

Regulation of microglial physiology by the microbiota

J Cook, M Prinz - Gut Microbes, 2022 - Taylor & Francis
The mammalian gut contains a large, complex community of microorganisms collectively
termed the microbiota. It is increasingly appreciated that gut microbes are closely integrated …

Gut microbiota and microbial metabolism in early risk of cardiometabolic disease

CL Gabriel, JF Ferguson - Circulation Research, 2023 - Am Heart Assoc
Cardiometabolic disease comprises cardiovascular and metabolic dysfunction and
underlies the leading causes of morbidity and mortality, both within the United States and …

The maternal gut microbiome in pregnancy: implications for the developing immune system

O Koren, L Konnikova, P Brodin, IU Mysorekar… - Nature Reviews …, 2024 - nature.com
The gut microbiome has important roles in host metabolism and immunity, and microbial
dysbiosis affects human physiology and health. Maternal immunity and microbial …

Investigating prenatal and perinatal factors on meconium microbiota: a systematic review and cohort study

J Turunen, MV Tejesvi, N Paalanne, T Pokka… - Pediatric …, 2024 - nature.com
Background The first-pass meconium has been suggested as a proxy for the fetal gut
microbiota because it is formed in utero. This systematic review and cohort study …

The human microbial exposome: expanding the Exposome-Explorer database with gut microbial metabolites

V Neveu, G Nicolas, A Amara, RM Salek, A Scalbert - Scientific Reports, 2023 - nature.com
Metabolites produced by the gut microbiota play an important role in the cross-talk with the
human host. Many microbial metabolites are biologically active and can pass the gut barrier …

Tissue-wide metabolomics reveals wide impact of gut microbiota on mice metabolite composition

I Zarei, VM Koistinen, M Kokla, A Klåvus, AF Babu… - Scientific Reports, 2022 - nature.com
The essential role of gut microbiota in health and disease is well recognized, but the
biochemical details that underlie the beneficial impact remain largely undefined. To maintain …