[HTML][HTML] Organoids and organ chips in ophthalmology
Recent advances have driven the development of stem cell-derived, self-organizing, three-
dimensional miniature organs, termed organoids, which mimic different eye tissues …
dimensional miniature organs, termed organoids, which mimic different eye tissues …
Potential of ocular transmission of SARS-CoV-2: a review
Purpose of review: to provide a prospective on the current mechanisms by which SARS-CoV-
2 enters cells and replicates, and its implications for ocular transmission. The literature was …
2 enters cells and replicates, and its implications for ocular transmission. The literature was …
[HTML][HTML] Human conjunctiva organoids to study ocular surface homeostasis and disease
M Bannier-Hélaouët, J Korving, Z Ma, H Begthel… - Cell Stem Cell, 2024 - cell.com
The conjunctival epithelium covering the eye contains two main cell types: mucus-producing
goblet cells and water-secreting keratinocytes, which present mucins on their apical surface …
goblet cells and water-secreting keratinocytes, which present mucins on their apical surface …
Lacrimal gland development: From signaling interactions to regenerative medicine
The lacrimal gland plays a pivotal role in keeping the ocular surface lubricated, and
protecting it from environmental exposure and insult. Dysfunction of the lacrimal gland …
protecting it from environmental exposure and insult. Dysfunction of the lacrimal gland …
Lacrimal gland regeneration: The unmet challenges and promise for dry eye therapy
Dry eye disease (DED) is a common multifactorial disease of the tear film and the ocular
surface. The problem of DED has gained attention globally, with millions of people affected …
surface. The problem of DED has gained attention globally, with millions of people affected …
Myoepithelial cell-driven acini contraction in response to oxytocin receptor stimulation is impaired in lacrimal glands of Sjögren's syndrome animal models
The purpose of the present studies was to investigate the impact of chronic inflammation of
the lacrimal gland, as occurs in Sjögren's syndrome, on the morphology and function of …
the lacrimal gland, as occurs in Sjögren's syndrome, on the morphology and function of …
Gene expression profiling and heterogeneity of nonspecific orbital inflammation affecting the lacrimal gland
Importance Although a variety of well-characterized diseases, such as sarcoidosis and
granulomatosis with polyangiitis, affect the lacrimal gland, many patients with dacryoadenitis …
granulomatosis with polyangiitis, affect the lacrimal gland, many patients with dacryoadenitis …
[HTML][HTML] Advances in functional restoration of the lacrimal glands
M Hirayama - Investigative Ophthalmology & Visual Science, 2018 - tvst.arvojournals.org
The lacrimal glands produce tears to support a healthy homeostatic environment on the
ocular surface. The lacrimal gland dysfunction characteristic of dry eye disease causes …
ocular surface. The lacrimal gland dysfunction characteristic of dry eye disease causes …
Current methodology and cell sources for lacrimal gland tissue engineering
Aqueous tears secreted by the lacrimal gland have vital importance in maintaining and
protecting the ocular surface health. Serious complications such as corneal ulceration …
protecting the ocular surface health. Serious complications such as corneal ulceration …
Crk mediates Csk-Hippo signaling independently of Yap tyrosine phosphorylation to induce cell extrusion
Src family kinases (SFKs), including Src, Fyn and Yes, play important roles in development
and cancer. Despite being first discovered as the Yes-associated protein, the 0regulation of …
and cancer. Despite being first discovered as the Yes-associated protein, the 0regulation of …