While continuous manufacturing (CM) of pharmaceutical solid-based drug products has
been shown to be advantageous for improving the product quality and process efficiency in …

Residence time distribution (RTD) has been widely applied across various fields of chemical
engineering, including pharmaceutical manufacturing, for applications such as material …

The pharmaceutical industry continuously looks for ways to improve its development and
manufacturing efficiency. In recent years, such efforts have been driven by the transition from …

In scope of achieving real-time release of tablets, quality attributes need to be monitored and
controlled through Process Analytical Technology tools such as near-infrared spectroscopy …

Residence time distribution (RTD) is a probability density function that describes the time
materials spend inside a system. It is a promising tool for mixing behavior characterization …

The influence of different tableting process parameters on lead-lag was studied by collecting
in-line near-infrared (NIR) spectra in the filling chamber of the tablet press feed frame and off …

Continuous manufacturing provides advantages compared to batch manufacturing and is
increasingly gaining importance in the pharmaceutical industry. In particular, the …

In the scope of 100% in-line quality control and real-time release of pharmaceutical tablets,
the authors present a flexible inspection module for in-line tablet analysis with integrated …

Residence time distribution (RTD) method has been widely used in the pharmaceutical
manufacturing for understanding powder dynamics within unit operations and continuous …

Purpose This study evaluates the use of the closed feed frame as a material sparing
approach to develop near-infrared (NIR) spectroscopic calibration models for monitoring …