Bacterial proteases are an extensive collection of enzymes that have vital roles in cell
viability, stress response and pathogenicity. Although their perturbation clearly offers the …

The public view on antibiotics as reliable medicines changed when reports about “resistant
superbugs” appeared in the news. While reasons for this resistance development are easily …

Drug combinations can expand options for antibacterial therapies but have not been
systematically tested in Gram-positive species. We profiled~ 8,000 combinations of 65 …

Antibiotic resistance is a key medical concern, with antibiotic use likely being an important
cause. However, here we describe an alternative route to clinically relevant antibiotic …

In prokaryotic cells and eukaryotic organelles, the ClpP protease plays an important role in
proteostasis. The disruption of the ClpP function has been shown to influence the infectivity …

Caseinolytic protease P (ClpP) represents a central bacterial degradation machinery that is
involved in cell homeostasis and pathogenicity. The functional role of ClpP has been studied …

Fast adaptation to environmental changes ensures bacterial survival, and proteolysis
represents a key cellular process in adaptation. The Clp protease system is a multi …

Covering: up to 2017 The bacterial Clp protease is a highly conserved and structurally
versatile machine. It has gained a lot of recognition during the last decade as a novel …

The Clp protease is an AAA+ protease that executes abnormally folded or malfunctioning
proteins, and has an important role in producing virulence factors, forming biofilms or …

The global spread of antibiotic resistance among important human pathogens emphasizes
the need to find new antibacterial drugs with a novel mode of action. The ClpP protease has …