Obesity is an epidemic and a public health threat. Medical weight management remains one
of the options for the treatment of excess weight and recent advances have revolutionized …

Brown adipose tissue (BAT) displays the unique capacity to generate heat through
uncoupled oxidative phosphorylation that makes it a very attractive therapeutic target for …

Aim To describe baseline characteristics and follow‐up data in patients with lipodystrophy
syndromes treated with metreleptin in a national reference network, in a real‐life setting …

Obesity has become a global epidemic in the modern world, significantly impacting the
global healthcare economy. Lifestyle interventions remain the primary approach to …

Context The effects of leptin, an adipocyte-derived hormone that signals overall energy
sufficiency, can only be studied in leptin-deficient conditions. In patients with lipodystrophy, a …

Abstract Context Rabson-Mendenhall syndrome (RMS) is caused by biallelic pathogenic
variants in the insulin receptor gene (INSR) leading to insulin-resistant diabetes …

Gluconeogenesis (GNG), the formation of glucose from noncarbohydrate precursors,
requires adenosine triphosphate (ATP). Previous studies have estimated the energetic cost …

Obesity is a chronic disease caused primarily by the imbalance between the amount of
calories supplied to the body and energy expenditure. Not only does it deteriorate the quality …

Introduction Obesity is the modern world's current epidemic, with substantial health and
economic impact. This study aimed to provide a narrative overview of the past, currently …

Lipodystrophy syndromes (LD) are a heterogeneous group of very rare congenital or
acquired disorders characterized by a generalized or partial lack of adipose tissue. They are …