The biology of mitochondrial uncoupling proteins

S Rousset, MC Alves-Guerra, J Mozo, B Miroux… - Diabetes, 2004 - Am Diabetes Assoc
Uncoupling proteins (UCPs) are mitochondrial transporters present in the inner membrane
of mitochondria. They are found in all mammals and in plants. They belong to the family of …

Animal models of multiple sclerosis—potentials and limitations

E Mix, H Meyer-Rienecker, HP Hartung… - Progress in neurobiology, 2010 - Elsevier
Experimental autoimmune encephalomyelitis (EAE) is still the most widely accepted animal
model of multiple sclerosis (MS). Different types of EAE have been developed in order to …

Therapeutic efficacy of IL-17 neutralization in murine experimental autoimmune encephalomyelitis

HH Hofstetter, SM Ibrahim, D Koczan, N Kruse… - Cellular …, 2005 - Elsevier
Experimental autoimmune encephalomyelitis (EAE) is widely regarded as an animal model
of the human disease multiple sclerosis. A multitude of studies has investigated the …

Global changes in optic nerve head gene expression after exposure to elevated intraocular pressure in a rat glaucoma model

EC Johnson, L Jia, WO Cepurna… - … & visual science, 2007 - iovs.arvojournals.org
purpose. In glaucoma, the optic nerve head (ONH) is the likely site of initial injury and
elevated intraocular pressure (IOP) is the best-known risk factor. This study determines …

Cytokines and cytokine profiles in human autoimmune diseases and animal models of autoimmunity

M Kunz, SM Ibrahim - Mediators of inflammation, 2009 - Wiley Online Library
The precise pathomechanisms of human autoimmune diseases are still poorly understood.
However, a deepened understanding of these is urgently needed to improve disease …

Inhibition of transcription factor NF-κB in the central nervous system ameliorates autoimmune encephalomyelitis in mice

G van Loo, R De Lorenzi, H Schmidt, M Huth… - Nature …, 2006 - nature.com
Activation of transcription factor NF-κB in the central nervous system (CNS) has been linked
to autoimmune demyelinating disease; however, it remains unclear whether its function is …

Respiration uncoupling and metabolism in the control of energy expenditure

D Ricquier - Proceedings of the Nutrition Society, 2005 - cambridge.org
Metabolic energy expenditure negatively regulates energy balance. Metabolic and catabolic
pathways contribute to energy expenditure. Catabolic pathways split C-containing …

[PDF][PDF] Cytosolic phospholipase A2 plays a key role in the pathogenesis of multiple sclerosis-like disease

A Kalyvas, S David - Neuron, 2004 - cell.com
Multiple sclerosis (MS) is an inflammatory demyelinating disease of the central nervous
system (CNS) that results in motor and sensory deficits. Although MS and its animal model …

Persistent activation of microglia is associated with neuronal dysfunction of callosal projecting pathways and multiple sclerosis-like lesions in relapsing–remitting …

S Rasmussen, Y Wang, P Kivisäkk, RT Bronson… - Brain, 2007 - academic.oup.com
The purpose of this study was to examine the influence of the “good-old-days” bias on
symptom reporting following mild traumatic brain injury (MTBI). The MTBI sample consisted …

Neuroprotective Effects of β-caryophyllene against dopaminergic neuron injury in a murine model of Parkinson's disease induced by MPTP

JM Viveros-Paredes, RE González-Castañeda… - Pharmaceuticals, 2017 - mdpi.com
Parkinson's disease (PD) is one of the most common neurodegenerative disorders and is
characterized by the loss of dopaminergic neurons in the substantia nigra (SN). Although the …